NFKBIB

Gene Symbol NFKBIB
Entrez Gene 4793
Alt Symbol IKBB, TRIP9
Species Human
Gene Type protein-coding
Description nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
Other Description I-kappa-B-beta|NF-kappa-B inhibitor beta|NF-kappa-BIB|TR-interacting protein 9|TRIP-9|ikB-B|ikB-beta|ikappaBbeta|thyroid receptor-interacting protein 9
Swissprots Q15653 A8K3F4 Q96BJ7
Accessions AAC41742 AAU10088 EAW56839 EAW56840 EAW56841 EAW56842 EAW56843 Q15653 AA044256 AB209784 BAD93021 AB362577 BAF81542 AI684894 AK057862 BAB71599 AK290569 BAF83258 BC007197 AAH07197 BC015528 AAH15528 BI520169 BM008311 BM449613 BQ440907 BT006743 AAP35389 BU150265 BU634404 BX111397 DA633677 DQ890633 ABM92250 DQ893804 ABM84730 XM_006723226 XP_006723289 XM_006723227 XP_006723290 NM_001243116 NP_001230045 NM_002503 NP_002494 NR_040515 NM_001001716
Function Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA- dependent inactivation. Association with inhibitor kappa B- interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Tissue Specificity Expressed in all tissues examined.
Top Pathways Cytosolic DNA-sensing pathway, Influenza A, Herpes simplex infection, Measles, Epstein-Barr virus infection

Phospho-IκBβ (Thr19/Ser23) Antibody (Human Specific) - 4921 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HT-29 cells treated with TNF-α (#2169, 20 ng/ml) and calyculin A (#9902, 100 nM) for 10 minutes as indicated, using Phospho-IκBβ (Thr19/Ser23) Antibody (upper) or IκBβ Antibody #9248 (lower).

IκBβ (7B4) Mouse mAb - 8635 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 7B4
Western blot analysis of extracts from various cell lines using IκBβ (7B4) Mouse mAb.

IκBβ Antibody - 9248 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from NIH-3T3 and PC12 cells, untreated or treated with calyculin A #9902 (50 nM for 15 minutes), using IκBβ Antibody.

Phospho-IκBβ (Ser19/23) Antibody (Mouse/Rat Specific) - 9245 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

IκB-β (C-20) - sc-945 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IκB-β (C-20): sc-945. Western blot analysis of IκB-β expression in CTLL-2 (A), RAW 264.7 (B) and WEHI-231 (C) whole cell lysates.

IκB-β (D-3) - sc-74451 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IκB-β (D-3): sc-74451. Western blot analysis of IκB-β expression in Ramos (A), CTLL-2 (B), RAW 264.7 (C), WEHI-3 (D) and KNRK (E) whole cell lysates.

IκB-β (D-8) - sc-74452 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IκB-β (D-8): sc-74452. Western blot analysis of IκB-β expression in Ramos (A), CTLL-2 (B), RAW 264.7 (C), WEHI-3 (D) and KNRK (E) whole cell lysates.

IκB-β (FL-359) - sc-9130 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IκB-β (FL-359): sc-9130. Western blot analysis of IκB-β expression in non-transfected: sc-110760 (A) and human IκB-β transfected: sc-113183 (B) 293 whole cell lysates.

IκB-β (N-20) - sc-969 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IκB-β (N-20): sc-969. Western blot analysis of IκB-β expression in non-transfected: sc-117752 (A) and human IκB-β transfected: sc-159438 (B) 293T whole cell lysates.

IκB-β (S-20) - sc-946 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IκB-β (S-20): sc-946. Immunofluorescence staining of methanol-fixed WEHI-231 cells showing cytoplasmic localization.

p-IκB-β (Ser 23) - sc-101715 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-IκB-β (Ser 23): sc-101715. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmic staining.

Anti-IkB beta (phospho S23) antibody - ab75746 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab75746, at a 1/50 dilution, staining IkB beta in paraffin embedded human breast carcinoma tissue by Immunohistochemistry, in the absence (left image) or presence (right image) of the immunizing phospho peptide.

Anti-IkB beta (phospho S23) antibody - ab51142 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IkB beta (phospho S23) antibody (ab51142) at 1/300 dilutionLane 1 : extracts from Hela cells treated with TNF-a with immunizing peptideLane 2 : extracts from Hela cells treated with TNF-aLysates/proteins at 0.02 µg/ml per lane.

Anti-IKB beta (phospho S23) antibody - ab195947 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IKB beta (phospho S23) antibody (ab195947) at 1/500 dilutionLane 1 : TNF-alpha treated HeLa whole cell lysate with antigen-specific peptideLane 2 : TNF-alpha treated HeLa whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-IkB beta (phospho T19) antibody - ab63510 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IKB beta antibody - ab7547 from Abcam

Prices $390.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of IkB beta by Immunoprecipitation in whole cell lysate from Huh-7 cells, using ab7547 at 4 µg/mg lysate for IP and ab1162 at a 1/1500 dilution for subsequent Western blot detection.Cells expressed recombinant IkB beta tagged with DDDDK. Protein A was used for the Immunoprecipitation step. Primary antibody incubated with matrix for 4 hours at 4°C.See Abreview

Anti-IKB beta antibody - ab42507 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IKB beta antibody (ab42507) at 0.5 µg/mlLane 1 : MarkerLane 2 : Jurkat Cell LysateSecondaryHRP conjugated anti-Rabbit IgG diluted 1:50,000-100,000

Anti-IKB beta antibody - ab116537 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-IKB beta antibody (ab116537) at 1/100 dilution + CEM cell line lysates at 35 µg

Anti-IKB beta antibody - ab136963 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-IKB beta antibody (ab136963) at 1/500 dilution + HT29 cell lysate at 30 µg

Anti-IkB beta antibody - ab55786 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-IkB beta antibody - ab58331 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
IkB beta antibody (ab58331) used in immunohistochemistry at 5ug/ml on formalin fixed and paraffin embedded human lung.

Anti-IKB beta antibody [7B4] - ab104844 from Abcam

Host Mouse
Clonality Monoclonal
Clone 7B4
Anti-IKB beta antibody [7B4] (ab104844) at 1/500 dilution + Jurkat cell lysate

Anti-IKB beta antibody [EPR5037] - ab109509 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5037
All lanes : Anti-IKB beta antibody [EPR5037] (ab109509) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : HeLa cell lysateLane 3 : THP-1 cell lysateLane 4 : MCF7 cell lysateLysates/proteins at 10 µg per lane.

Anti-NFKBIB / IKB Beta / IKBB Antibody - LS-C73508 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-NFKBIB / IKB Beta / IKBB Antibody (aa88-139) - LS-C30857 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
HepG2 Cell Lysate
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