| Gene Symbol | NFKBIB |
|---|---|
| Entrez Gene | 4793 |
| Alt Symbol | IKBB, TRIP9 |
| Species | Human |
| Gene Type | protein-coding |
| Description | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta |
| Other Description | I-kappa-B-beta|NF-kappa-B inhibitor beta|NF-kappa-BIB|TR-interacting protein 9|TRIP-9|ikB-B|ikB-beta|ikappaBbeta|thyroid receptor-interacting protein 9 |
| Swissprots | Q15653 A8K3F4 Q96BJ7 |
| Accessions | AAC41742 AAU10088 EAW56839 EAW56840 EAW56841 EAW56842 EAW56843 Q15653 AA044256 AB209784 BAD93021 AB362577 BAF81542 AI684894 AK057862 BAB71599 AK290569 BAF83258 BC007197 AAH07197 BC015528 AAH15528 BI520169 BM008311 BM449613 BQ440907 BT006743 AAP35389 BU150265 BU634404 BX111397 DA633677 DQ890633 ABM92250 DQ893804 ABM84730 XM_006723226 XP_006723289 XM_006723227 XP_006723290 NM_001243116 NP_001230045 NM_002503 NP_002494 NR_040515 NM_001001716 |
| Function | Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA- dependent inactivation. Association with inhibitor kappa B- interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
| Tissue Specificity | Expressed in all tissues examined. |
| Top Pathways | Cytosolic DNA-sensing pathway, Influenza A, Herpes simplex infection, Measles, Epstein-Barr virus infection |