Gene Symbol | CDC5L |
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Entrez Gene | 988 |
Alt Symbol | CDC5, CDC5-LIKE, CEF1, PCDC5RP, dJ319D22.1 |
Species | Human |
Gene Type | protein-coding |
Description | cell division cycle 5-like |
Other Description | CDC5 cell division cycle 5-like|Cdc5-related protein|cell division cycle 5-like protein|dJ319D22.1 (CDC5-like protein)|pombe cdc5-related protein |
Swissprots | Q76N46 Q99459 Q99974 |
Accessions | AAR89913 EAX04270 Q99459 AB007892 BAA24862 AK128737 BAG54722 AK299738 BAG61633 BC001568 AAH01568 BG187521 BG497404 BM829346 D85423 BAA20885 DC422730 DQ891623 ABM82549 DQ894814 ABM85740 U86753 AAB61210 XM_006715289 XP_006715352 XR_926346 NM_001253 NP_001244 |
Function | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9598309}. Nucleus speckle {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:10827081, ECO:0000269|PubMed:11544257}. Cytoplasm {ECO:0000269|PubMed:9038199}. Note=May shuttle between cytoplasm and nucleus. {ECO:0000269|PubMed:9038199}. |
Tissue Specificity | Ubiquitously expressed in both fetal and adult tissues. {ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9598309, ECO:0000269|PubMed:9632794}. |
Top Pathways | Spliceosome |
Cdc5L CRISPR/Cas9 KO Plasmid (h) - sc-404611 from Santa Cruz Biotechnology
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Cdc5L HDR Plasmid (h) - sc-404611-HDR from Santa Cruz Biotechnology
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Cdc5L Double Nickase Plasmid (h) - sc-404611-NIC from Santa Cruz Biotechnology
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Cdc5L Double Nickase Plasmid (h2) - sc-404611-NIC-2 from Santa Cruz Biotechnology
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Cdc5L CRISPR Activation Plasmid (h) - sc-404611-ACT from Santa Cruz Biotechnology
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Cdc5L CRISPR Activation Plasmid (h2) - sc-404611-ACT-2 from Santa Cruz Biotechnology
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Cdc5L Lentiviral Activation Particles (h) - sc-404611-LAC from Santa Cruz Biotechnology
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Cdc5L Lentiviral Activation Particles (h2) - sc-404611-LAC-2 from Santa Cruz Biotechnology
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Cdc5L siRNA (h) - sc-62088 from Santa Cruz Biotechnology
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Cdc5L shRNA Plasmid (h) - sc-62088-SH from Santa Cruz Biotechnology
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Cdc5L shRNA (h) Lentiviral Particles - sc-62088-V from Santa Cruz Biotechnology
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CDC5L RNAi - H00000988-R01 from Novus Biologicals
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MISSION® esiRNA - EHU046781 from Sigma-Aldrich
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MISSION® esiRNA - EHU102451 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5794 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5794 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03355 from Sigma-Aldrich
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CDC5L siRNA (Human) - CRH0703 from Cohesion Biosciences
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CDC5L - MBS8213475 from MyBioSource
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shRNA set against Human CDC5L (NM_001253.3) - SHH259957 from Creative biogene
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CDC5L shRNA Plasmid (Human) - CHH0703 from Cohesion Biosciences
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CDC5L miRNA 3'UTR clone - MiUTR3H-05369 from Creative biogene
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