Gene Symbol | APOC1 |
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Entrez Gene | 341 |
Alt Symbol | Apo-CI, ApoC-I |
Species | Human |
Gene Type | protein-coding |
Description | apolipoprotein C-I |
Other Description | apo-CIB|apoC-IB|apolipoprotein C-I variant I|apolipoprotein C1 |
Swissprots | Q6IB97 B2R526 P02654 |
Accessions | AAA51763 AAA88018 AAD02506 AAQ91813 ACN81312 EAW57307 EAW57308 P02654 AF308154 AAG49499 AF308155 AAG49500 AI310334 AI885116 AK225971 AK312036 BAG34973 AM392727 CAL37605 BC009698 AAH09698 BC055093 AAH55093 BT007142 AAP35806 CR456907 CAG33188 GQ129384 ACT64518 GQ129385 ACT64519 M27359 AAA51762 X00570 CAA25235 XM_005258855 XP_005258912 NM_001645 NP_001636 |
Function | Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein. {ECO:0000269|PubMed:17339654, ECO:0000303|PubMed:25160599}. |
Subcellular Location | Secreted {ECO:0000303|PubMed:2835369}. |
Tissue Specificity | Synthesized mainly in liver and to a minor degree in intestine. Also found in the lung and spleen. {ECO:0000269|PubMed:2835369}. |
apoC1 CRISPR/Cas9 KO Plasmid (h) - sc-403713 from Santa Cruz Biotechnology
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apoC1 HDR Plasmid (h) - sc-403713-HDR from Santa Cruz Biotechnology
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apoC1 Double Nickase Plasmid (h) - sc-403713-NIC from Santa Cruz Biotechnology
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apoC1 Double Nickase Plasmid (h2) - sc-403713-NIC-2 from Santa Cruz Biotechnology
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apoC1 CRISPR Activation Plasmid (h) - sc-403713-ACT from Santa Cruz Biotechnology
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apoC1 CRISPR Activation Plasmid (h2) - sc-403713-ACT-2 from Santa Cruz Biotechnology
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apoC1 Lentiviral Activation Particles (h) - sc-403713-LAC from Santa Cruz Biotechnology
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apoC1 Lentiviral Activation Particles (h2) - sc-403713-LAC-2 from Santa Cruz Biotechnology
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apoC-I siRNA (h) - sc-97370 from Santa Cruz Biotechnology
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apoC-I shRNA Plasmid (h) - sc-97370-SH from Santa Cruz Biotechnology
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apoC-I shRNA (h) Lentiviral Particles - sc-97370-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU125971 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3342 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3342 from Sigma-Aldrich
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APOC1 siRNA (Human) - CRH0240 from Cohesion Biosciences
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Apolipoprotein C1 RNAi - H00000341-R01 from Novus Biologicals
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APOC1 - MBS8223584 from MyBioSource
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shRNA set against Human APOC1 (NM_001645.3) - SHH238482 from Creative biogene
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shRNA set against Human APOC1(NM_001645.3) - SHG065521 from Creative biogene
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Human APOC1 siRNA - orb260742 from Biorbyt
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APOC1 shRNA Plasmid (Human) - CHH0240 from Cohesion Biosciences
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APOC1 miRNA 3'UTR clone - MiUTR1H-00477 from Creative biogene
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