| Gene Symbol |
Zranb1
|
| Entrez Gene |
360216
|
| Alt Symbol |
9330160G10Rik, D7Wsu87e, Gm1956, Trabid
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
zinc finger, RAN-binding domain containing 1
|
| Other Description |
TRAF-binding protein|ubiquitin thioesterase Zranb1|zinc finger Ran-binding domain-containing protein 1
|
| Swissprots |
Q7M760
|
| Accessions |
EDL17757 EDL17758 Q7M760 AJ250693 CAC08505 AK005926 AK010069 AK020376 AK087360 AK140426 BAE24381 AK163589 BAE37409 BC145520 BC168391 AAI68391 BN000126 CAD67576 XM_006507966 XP_006508029 XM_006507967 XP_006508030 XM_006507968 XP_006508031 XM_006507969 XP_006508032 XM_011241836 XP_011240138 XM_011241837 XP_011240139 NM_207302 NP_997185
|
| Function |
Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'- linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Enriched in punctate localization in the cytoplasm. {ECO:0000250}.
|