Gene Symbol | Zranb1 |
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Entrez Gene | 360216 |
Alt Symbol | 9330160G10Rik, D7Wsu87e, Gm1956, Trabid |
Species | Mouse |
Gene Type | protein-coding |
Description | zinc finger, RAN-binding domain containing 1 |
Other Description | TRAF-binding protein|ubiquitin thioesterase Zranb1|zinc finger Ran-binding domain-containing protein 1 |
Swissprots | Q7M760 |
Accessions | EDL17757 EDL17758 Q7M760 AJ250693 CAC08505 AK005926 AK010069 AK020376 AK087360 AK140426 BAE24381 AK163589 BAE37409 BC145520 BC168391 AAI68391 BN000126 CAD67576 XM_006507966 XP_006508029 XM_006507967 XP_006508030 XM_006507968 XP_006508031 XM_006507969 XP_006508032 XM_011241836 XP_011240138 XM_011241837 XP_011240139 NM_207302 NP_997185 |
Function | Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'- linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Enriched in punctate localization in the cytoplasm. {ECO:0000250}. |
TRABID CRISPR/Cas9 KO Plasmid (m) - sc-436169 from Santa Cruz Biotechnology
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TRABID HDR Plasmid (m) - sc-436169-HDR from Santa Cruz Biotechnology
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TRABID Double Nickase Plasmid (m) - sc-436169-NIC from Santa Cruz Biotechnology
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TRABID Double Nickase Plasmid (m2) - sc-436169-NIC-2 from Santa Cruz Biotechnology
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TRABID CRISPR Activation Plasmid (m) - sc-436169-ACT from Santa Cruz Biotechnology
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TRABID CRISPR Activation Plasmid (m2) - sc-436169-ACT-2 from Santa Cruz Biotechnology
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TRABID Lentiviral Activation Particles (m) - sc-436169-LAC from Santa Cruz Biotechnology
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TRABID Lentiviral Activation Particles (m2) - sc-436169-LAC-2 from Santa Cruz Biotechnology
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TRABID siRNA (m) - sc-154577 from Santa Cruz Biotechnology
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TRABID shRNA Plasmid (m) - sc-154577-SH from Santa Cruz Biotechnology
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TRABID shRNA (m) Lentiviral Particles - sc-154577-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN45367 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND45367 from Sigma-Aldrich
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ZRANB1 siRNA (Mouse) - CRN4765 from Cohesion Biosciences
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ZRANB1 - MBS8210704 from MyBioSource
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shRNA set against Mouse ZRANB1 (NM_207302.1) - SHH455812 from Creative biogene
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shRNA set against Mouse Zranb1(NM_207302.1) - SHL163002 from Creative biogene
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ZRANB1 shRNA Plasmid (Mouse) - CHN4765 from Cohesion Biosciences
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ZRANB1 miRNA 3'UTR clone - MiUTR1M-13210 from Creative biogene
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