DCC

Gene Symbol DCC
Entrez Gene 1630
Alt Symbol CRC18, CRCR1, IGDCC1, MRMV1, NTN1R1
Species Human
Gene Type protein-coding
Description DCC netrin 1 receptor
Other Description colorectal cancer suppressor|colorectal tumor suppressor|deleted in colorectal cancer protein|deleted in colorectal carcinoma|immunoglobulin superfamily DCC subclass member 1|immunoglobulin superfamily, DCC subclass, member 1|netrin receptor DCC|tumor suppressor protein DCC
Swissprots P43146
Accessions AAA52174 AAA52175 AAA52176 AAA52177 AAA52178 AAA52179 AAA52180 AAA52181 AAB31484 EAW62991 EAW62992 EAW62993 EAW62994 P43146 AK302643 BAG63884 AK310385 AW949550 BC036524 AAH36524 BC152808 AAI52809 M32292 AAA35751 X76132 CAA53735 XM_011525843 XP_011524145 XM_011525844 XP_011524146 XM_011525845 XP_011524147 XM_011525846 XP_011524148 NM_005215 NP_005206
Function Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. {ECO:0000269|PubMed:8187090, ECO:0000269|PubMed:8861902}.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells. {ECO:0000269|PubMed:7926722}.
Top Pathways Axon guidance, Colorectal cancer

DCC (A-20) - sc-6535 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DCC (A-20): sc-6535. Western blot analysis of DCC expression in IMR-32 (A), U-87 MG (B) and SW480 (C) whole cell lysates.

DCC (C-18) - sc-6534 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DCC (C-18): sc-6534. Western blot analysis of DCC expression in non-transfected: sc-117752 (A) and mouse DCC transfected: sc-375146 (B) 293T whole cell lysates.

DCC (H-205) - sc-11437 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-DCC antibody - ab125280 from Abcam

Prices $372.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DCC antibody - ab118597 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab118597, at 5 µg/ml, staining DCC in formalin fixed, paraffin embedded Human adrenal tissue by Immunohistochemistry.

Anti-DCC antibody - ab196598 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of LOVO cells labelling DCC using ab196598 at 1/100 dilution. The image on the right is treated with the synthesized peptide.

Anti-DCC antibody - ab118918 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-DCC antibody (ab118918) at 1 µg/ml + ACHN cell lysate at 10 µg

Anti-DCC antibody - ab54543 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DCC antibody - ab10525 from Abcam

Host Goat
Clonality Polyclonal

Anti-DCC antibody [AF5] - ab16793 from Abcam

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone AF5
Overlay histogram showing UG-87 cells stained with ab16793 (red line). The cells were fixed with 80% methanol (5 min) and incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab16793, 1µg/1x106 cells) for 30 min at 22ºC. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 2µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed.Please note that Abcam do not have any data for use of this antibody on non-fixed cells. We welcome any customer feedback.

Anti-DCC antibody [DM51] - ab49169 from Abcam

Host Mouse
Clonality Monoclonal
Clone DM51

Anti-DCC antibody - Azide free - ab201260 from Abcam

Prices $372.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DCC Antibody (Extracellular Domain) - LS-C64527 from LifeSpan Bioscience

Prices $485.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-DCC Antibody (aa1323-1447) - LS-C123377 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-DCC Antibody (aa441-490) - LS-C119543 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of LOVO cells, using DCC Antibody. The picture on the right is treated with the synthesized peptide.

Anti-DCC Antibody (Internal) - LS-C210068 from LifeSpan Bioscience

Prices $295.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-DCC Antibody (aa1391-1417, APC) - LS-C255892 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DCC Antibody (aa1391-1417, Biotin) - LS-C255893 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DCC Antibody (aa1079-1128) - LS-C116330 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DCC antibody LS-C116330 Western blot of ACHN lysate.

Anti-DCC Antibody (aa1391-1417, AP) - LS-C255891 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DCC Antibody (aa1391-1417) - LS-C158192 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Mouse Dcc Antibody western blot of mouse Neuro-2a cell line lysates (35 ug/lane). The Dcc antibody detected the Dcc protein (arrow).

Anti-DCC Antibody (aa1391-1417, FITC) - LS-C255894 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DCC Antibody (aa1391-1417, Azide-free, HRP) - LS-C255895 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DCC Antibody (aa643-670, AP) - LS-C255897 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DCC Antibody (aa1391-1417, PE) - LS-C255896 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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