DCC

Gene Symbol DCC
Entrez Gene 1630
Alt Symbol CRC18, CRCR1, IGDCC1, MRMV1, NTN1R1
Species Human
Gene Type protein-coding
Description DCC netrin 1 receptor
Other Description colorectal cancer suppressor|colorectal tumor suppressor|deleted in colorectal cancer protein|deleted in colorectal carcinoma|immunoglobulin superfamily DCC subclass member 1|immunoglobulin superfamily, DCC subclass, member 1|netrin receptor DCC|tumor suppressor protein DCC
Swissprots P43146
Accessions AAA52174 AAA52175 AAA52176 AAA52177 AAA52178 AAA52179 AAA52180 AAA52181 AAB31484 EAW62991 EAW62992 EAW62993 EAW62994 P43146 AK302643 BAG63884 AK310385 AW949550 BC036524 AAH36524 BC152808 AAI52809 M32292 AAA35751 X76132 CAA53735 XM_011525843 XP_011524145 XM_011525844 XP_011524146 XM_011525845 XP_011524147 XM_011525846 XP_011524148 NM_005215 NP_005206
Function Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. {ECO:0000269|PubMed:8187090, ECO:0000269|PubMed:8861902}.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells. {ECO:0000269|PubMed:7926722}.
Top Pathways Axon guidance, Colorectal cancer

DCC CRISPR/Cas9 KO Plasmid (h) - sc-401035 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DCC HDR Plasmid (h) - sc-401035-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DCC Double Nickase Plasmid (h) - sc-401035-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DCC Double Nickase Plasmid (h2) - sc-401035-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DCC CRISPR Activation Plasmid (h) - sc-401035-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DCC CRISPR Activation Plasmid (h2) - sc-401035-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DCC Lentiviral Activation Particles (h) - sc-401035-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DCC Lentiviral Activation Particles (h2) - sc-401035-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DCC siRNA (h) - sc-35183 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DCC shRNA Plasmid (h) - sc-35183-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DCC shRNA (h) Lentiviral Particles - sc-35183-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DCC RNAi - H00001630-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU014471 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6978 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6978 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

DCC siRNA (Human) - CRH1147 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DCC - MBS8207369 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DCC (NM_005215.3) - SHH275061 from Creative biogene

Category siRNA
Species Reactivities Human

Human DCC siRNA - orb261649 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DCC shRNA Plasmid (Human) - CHH1147 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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