CD63
| Gene Symbol | CD63 |
|---|---|
| Entrez Gene | 967 |
| Alt Symbol | LAMP-3, ME491, MLA1, OMA81H, TSPAN30 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD63 molecule |
| Other Description | CD63 antigen|CD63 antigen (melanoma 1 antigen)|granulophysin|lysosomal-associated membrane protein 3|lysosome-associated membrane glycoprotein 3|melanoma-associated antigen ME491|melanoma-associated antigen MLA1|ocular melanoma-associated antigen|tetraspanin-30|tspan-30 |
| Swissprots | F8VZE2 P08962 Q9UCG6 Q5TZP3 Q8N6Z9 |
| Accessions | CAA44519 EAW96827 EAW96828 EAW96829 P08962 AA583189 AF508304 AAM34259 AK311893 BAG34834 AL582859 AV650763 BC002349 AAH02349 BC013017 AAH13017 BE407235 BG478842 BG766593 BQ434569 BT007073 AAP35736 BT020137 AAV38939 BT020138 AAV38940 BU167765 BU190521 BU960599 CB128206 CD250685 CN296813 CN296834 CN484590 CR542096 CAG46893 DB495090 DQ891248 ABM82174 DQ894433 ABM85359 EB386351 KF998086 AHI51903 M58485 M59907 AAA63235 S93788 AAB21617 X07982 CAA30792 NM_001257389 NP_001244318 NM_001257390 NP_001244319 NM_001257391 NP_001244320 NM_001257392 NP_001244321 NM_001257400 NP_001244329 NM_001257401 NP_001244330 NM_001267698 NP_001254627 NM_001780 NP_001771 NM_001040034 |
| Function | Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. {ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:2 |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endosome, multivesicular body. Melanosome. Note=Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules. Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies. |
| Tissue Specificity | Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages. {ECO:0000269|PubMed:19640571}. |
| Top Pathways | Lysosome, Proteoglycans in cancer |
Search more
