CD63

Gene Symbol CD63
Entrez Gene 967
Alt Symbol LAMP-3, ME491, MLA1, OMA81H, TSPAN30
Species Human
Gene Type protein-coding
Description CD63 molecule
Other Description CD63 antigen|CD63 antigen (melanoma 1 antigen)|granulophysin|lysosomal-associated membrane protein 3|lysosome-associated membrane glycoprotein 3|melanoma-associated antigen ME491|melanoma-associated antigen MLA1|ocular melanoma-associated antigen|tetraspanin-30|tspan-30
Swissprots F8VZE2 P08962 Q9UCG6 Q5TZP3 Q8N6Z9
Accessions CAA44519 EAW96827 EAW96828 EAW96829 P08962 AA583189 AF508304 AAM34259 AK311893 BAG34834 AL582859 AV650763 BC002349 AAH02349 BC013017 AAH13017 BE407235 BG478842 BG766593 BQ434569 BT007073 AAP35736 BT020137 AAV38939 BT020138 AAV38940 BU167765 BU190521 BU960599 CB128206 CD250685 CN296813 CN296834 CN484590 CR542096 CAG46893 DB495090 DQ891248 ABM82174 DQ894433 ABM85359 EB386351 KF998086 AHI51903 M58485 M59907 AAA63235 S93788 AAB21617 X07982 CAA30792 NM_001257389 NP_001244318 NM_001257390 NP_001244319 NM_001257391 NP_001244320 NM_001257392 NP_001244321 NM_001257400 NP_001244329 NM_001257401 NP_001244330 NM_001267698 NP_001254627 NM_001780 NP_001771 NM_001040034
Function Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. {ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:2
Subcellular Location Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endosome, multivesicular body. Melanosome. Note=Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules. Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies.
Tissue Specificity Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages. {ECO:0000269|PubMed:19640571}.
Top Pathways Lysosome, Proteoglycans in cancer

CD63 (E-12) - sc-365604 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD63 (E-12): sc-365604. Western blot analysis of CD63 expression in T24 whole cell lysate.

CD63 (H-193) - sc-15363 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CD63 (H-193): sc-15363. Western blot analysis of CD63 expression in T24 (A), SK-MEL-28 (B), CCD-1064Sk (C), C32 (D) and THP-1 (E) whole cell lysates.

CD63 (MX-49.129.5) - sc-5275 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD63 (MX-49.129.5): sc-5275. Western blot analysis of CD63 expression in T24 (A), SK-MEL-28 (B), CCD-1064Sk (C) and C32 (D) whole cell lysates.

CD63 (K-19) - sc-7080 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CD63 (K-19): sc-7080. Immunofluorescence staining of methanol-fixed C32 cells showing cytoplasmic localization.

CD63 (Y-18) - sc-31211 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CD63 (Y-18): sc-31211. Western blot analysis of human recombinant CD63 fusion protein.

CD63 (R-13) - sc-31213 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CD63 (NK1/C3) - sc-59286 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD63 (NK1/C3): sc-59286. Western blot analysis of CD63 expression in T24 whole cell lysate.

CD63 (M-13) - sc-31214 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CD63 (H-14) - sc-31210 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CD63 (H-14): sc-31210. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing cytoplasmic and membrane staining of trophoblastic cells.

CD63 (CLB-180) - sc-59284 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
CD63 (CLB-180): sc-59284. Western blot analysis of CD63 expression in T24 whole cell lysate.

CD63 (AHN16.1/46-4-5) - sc-66166 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

CD63 (3H1626) - sc-71493 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
CD63 (3H1626): sc-71493. Indirect FCM analysis of human peripheral blood leukocytes stained with LAMP-3 (MEM-259), followed by PE-conjugated goat anti-mouse IgG<sub>1</sub>: sc-3764. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-3877.

Anti-CD63 antibody - ab68418 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CD63 antibody (ab68418) at 1 µg/ml + HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-CD63 antibody - ab118307 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab118307 stained A431 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab118307, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM

Anti-CD63 antibody - ab199921 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CD63 antibody (ab199921) at 1/1000 dilutionLane 1 : Total cell extract from mouse brainLane 2 : Total cell extract from mouse thymusLane 3 : Total cell extract from HeLa cellsLane 4 : Total cell extract from Jurkat cells

Anti-CD63 antibody - ab135276 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human lung carcinoma tissue labelled with ab135276 at 1/50 dilution.

Anti-CD63 antibody [CLB-180] - ab23792 from Abcam

Prices $372.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone CLB-180

Anti-CD63 antibody [EPR5702] - ab134045 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5702
All lanes : Anti-CD63 antibody [EPR5702] (ab134045) at 1/1000 dilutionLane 1 : Human platelet lysateLane 2 : Human melanoma lysateLane 3 : HL60 lysateLane 4 : A375 lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-CD63 antibody [MEM-259] - ab8219 from Abcam

Prices $401.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MEM-259
ab8219 staining CD63 in human fibrosarcoma cells by Immunocytochemistry/ Immunofluorescence. Cells were fixed with paraformaldehyde. Samples were incubated with primary antibody which was used diluted to 10 µg/ml for 1 hour at 20°C. An Alexa Fluor®555-conjugated donkey monoclonal to mouse IgG was used at dilution at 1/500 as secondary antibody.See Abreview

Anti-CD63 antibody [MEM-259] (Allophycocyanin) - ab65840 from Abcam

Prices $370.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone MEM-259

Anti-CD63 antibody [MEM-259] (Biotin) - ab134331 from Abcam

Prices $373.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MEM-259

Anti-CD63 antibody [MEM-259] (FITC) - ab18235 from Abcam

Prices $188.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone MEM-259
ab18235 staining CD63 in human peripheral blood lymphocytes from a patient with allergy to bee venom after stimulation with bee venom, analysed by Flow Cytometry.

Anti-CD63 antibody [MEM-259] (PerCP) - ab77227 from Abcam

Prices $190.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone MEM-259

Anti-CD63 antibody [MEM-259], prediluted (PerCP/Cy5.5®) - ab157313 from Abcam

Prices $370.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone MEM-259

Anti-CD63 antibody [MEM-259], prediluted (Phycoerythrin) - ab18236 from Abcam

Prices $185.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone MEM-259
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