CBR1

Gene Symbol	CBR1
Entrez Gene	873
Alt Symbol	CBR, SDR21C1, hCBR1
Species	Human
Gene Type	protein-coding
Description	carbonyl reductase 1
Other Description	15-hydroxyprostaglandin dehydrogenase|NADPH-dependent carbonyl reductase 1|carbonyl reductase (NADPH) 1|carbonyl reductase [NADPH] 1|prostaglandin 9-ketoreductase|prostaglandin-E(2) 9-reductase|short chain dehydrogenase/reductase family 21C member 1|short chain dehydrogenase/reductase family 21C, member 1
Swissprots	Q3LHW8 B2RBZ7 B4DFK7 P16152
Accessions	AAA17881 ABK97430 BAA33498 BAA89424 BAA95508 EAX09752 EAX09753 EAX09754 EAX09755 P16152 AB124848 BAE45940 AK294142 BAG57468 AK308691 AK311219 AK314879 BAG37394 AL548852 BC002511 AAH02511 BC015640 AAH15640 BT019843 AAV38646 CR541708 CAG46509 DQ892353 ABM83279 DQ895559 ABM86485 J04056 AAA52070 N51716 NM_001286789 NP_001273718 NM_001757 NP_001748
Function	NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. {ECO:0000269|PubMed:15799708, ECO:0000269|PubMed:17912391, ECO:0000269|PubMed:18449627, ECO:0000269|PubMed:18826943}.
Subcellular Location	Cytoplasm.
Top Pathways	Chemical carcinogenesis, Arachidonic acid metabolism, Metabolism of xenobiotics by cytochrome P450

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CBR1 full length protein - ab85336 from Abcam Category Protein Prices $228.00, $866.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Human CBR1 full length protein - ab117172 from Abcam Category Protein Prices $62.00 Sizes 5 µg Source E. coli Species Human

Human CBR1 peptide - ab22991 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

CBR / CBR1 Antibody Blocking Peptide - LS-E25386 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CBR / CBR1 Antibody Blocking Peptide - LS-E16712 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CBR1 Recombinant Protein - H00000873-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 25 ug 10 ug Species Human

CBR1 Protein - NBC1-26370 from Novus Biologicals Category Protein Prices $309.00 Sizes 100 µg

CBR1 blocking peptide - GTX89841-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Recombinant human Carbonyl reductase [NADPH] 1 (OPCA01011) - OPCA01011 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Recombinant human Carbonyl reductase [NADPH] 1 protein (OPCA01012) - OPCA01012 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

CBR1 Protein (OPPA02099) - OPPA02099 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human CBR1 protein - orb245578 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human CBR1 protein - orb245577 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human Carbonyl Reductase-1 protein - orb90053 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

Yeast CBR1 protein - orb245778 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Yeast

CBR1 Immunizing peptide - orb17533 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

Carbonyl Reductase 1 Blocking Peptide - 33R-1155 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Carbonyl Reductase 1 Blocking Peptide - 33R-7140 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CBR1 protein - 30R-1311 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

CBR1 Blocking Peptide - abx062361 from Abbexa Category Peptide Species Human, Monkey

CBR1 Peptide - AC21-0214-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Carbonyl reductase 1 (1-277) - AR09192PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

Carbonyl reductase 1 (1-277) - AR09192PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

Carbonyl Reductase-1, Human Recombinant - 228-10176-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Recombinant Human CBR1 - 228-10176-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

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