CBR1

Gene Symbol CBR1
Entrez Gene 873
Alt Symbol CBR, SDR21C1, hCBR1
Species Human
Gene Type protein-coding
Description carbonyl reductase 1
Other Description 15-hydroxyprostaglandin dehydrogenase|NADPH-dependent carbonyl reductase 1|carbonyl reductase (NADPH) 1|carbonyl reductase [NADPH] 1|prostaglandin 9-ketoreductase|prostaglandin-E(2) 9-reductase|short chain dehydrogenase/reductase family 21C member 1|short chain dehydrogenase/reductase family 21C, member 1
Swissprots Q3LHW8 B2RBZ7 B4DFK7 P16152
Accessions AAA17881 ABK97430 BAA33498 BAA89424 BAA95508 EAX09752 EAX09753 EAX09754 EAX09755 P16152 AB124848 BAE45940 AK294142 BAG57468 AK308691 AK311219 AK314879 BAG37394 AL548852 BC002511 AAH02511 BC015640 AAH15640 BT019843 AAV38646 CR541708 CAG46509 DQ892353 ABM83279 DQ895559 ABM86485 J04056 AAA52070 N51716 NM_001286789 NP_001273718 NM_001757 NP_001748
Function NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. {ECO:0000269|PubMed:15799708, ECO:0000269|PubMed:17912391, ECO:0000269|PubMed:18449627, ECO:0000269|PubMed:18826943}.
Subcellular Location Cytoplasm.
Top Pathways Chemical carcinogenesis, Arachidonic acid metabolism, Metabolism of xenobiotics by cytochrome P450

Carbonyl reductase 1 CRISPR/Cas9 KO Plasmid (h) - sc-402755 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Carbonyl reductase 1 HDR Plasmid (h) - sc-402755-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Carbonyl reductase 1 Double Nickase Plasmid (h) - sc-402755-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Carbonyl reductase 1 Double Nickase Plasmid (h2) - sc-402755-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Carbonyl reductase 1 CRISPR Activation Plasmid (h) - sc-402755-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Carbonyl reductase 1 CRISPR Activation Plasmid (h2) - sc-402755-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Carbonyl reductase 1 Lentiviral Activation Particles (h) - sc-402755-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Carbonyl reductase 1 Lentiviral Activation Particles (h2) - sc-402755-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Carbonyl reductase 1 siRNA (h) - sc-72791 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Carbonyl reductase 1 shRNA Plasmid (h) - sc-72791-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Carbonyl reductase 1 shRNA (h) Lentiviral Particles - sc-72791-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU155751 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5416 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5416 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02796 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02796

CBR1 siRNA (Human) - CRH0616 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CBR1 RNAi - H00000873-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CBR1 - MBS8229873 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CBR1 (NM_001757.2) - SHH255405 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CBR1(NM_001757.2) - SHG144991 from Creative biogene

Category siRNA
Species Reactivities Human

Human Prostaglandin-E(2) 9-reductase siRNA - orb261118 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CBR1 shRNA Plasmid (Human) - CHH0616 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CBR1 miRNA 3'UTR clone - MiUTR1H-01706 from Creative biogene

Species Reactivities Human
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