| Gene Symbol |
Atf1
|
| Entrez Gene |
11908
|
| Alt Symbol |
-
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
activating transcription factor 1
|
| Other Description |
TCR-ATF1|cAMP-dependent transcription factor ATF-1|cyclic AMP-dependent transcription factor ATF-1
|
| Swissprots |
P81269
|
| Accessions |
EDL04102 P81269 AK010428 BAB26930 AK040300 AK042385 AK144511 AK148500 BC006871 AAH06871 BY733806 M63725 AAA40395 XM_006520351 XP_006520414 XM_006520352 XP_006520415 NM_007497 NP_031523
|
| Function |
Binds the cAMP response element (CRE) (consensus: 5'- GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
HTLV-I infection, Transcriptional misregulation in cancer
|