Gene Symbol | Atf1 |
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Entrez Gene | 11908 |
Alt Symbol | - |
Species | Mouse |
Gene Type | protein-coding |
Description | activating transcription factor 1 |
Other Description | TCR-ATF1|cAMP-dependent transcription factor ATF-1|cyclic AMP-dependent transcription factor ATF-1 |
Swissprots | P81269 |
Accessions | EDL04102 P81269 AK010428 BAB26930 AK040300 AK042385 AK144511 AK148500 BC006871 AAH06871 BY733806 M63725 AAA40395 XM_006520351 XP_006520414 XM_006520352 XP_006520415 NM_007497 NP_031523 |
Function | Binds the cAMP response element (CRE) (consensus: 5'- GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus. |
Top Pathways | HTLV-I infection, Transcriptional misregulation in cancer |
ATF-1 CRISPR/Cas9 KO Plasmid (m) - sc-419225 from Santa Cruz Biotechnology
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ATF-1 HDR Plasmid (m) - sc-419225-HDR from Santa Cruz Biotechnology
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ATF-1 Double Nickase Plasmid (m) - sc-419225-NIC from Santa Cruz Biotechnology
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ATF-1 Double Nickase Plasmid (m2) - sc-419225-NIC-2 from Santa Cruz Biotechnology
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ATF-1 CRISPR Activation Plasmid (m) - sc-419225-ACT from Santa Cruz Biotechnology
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ATF-1 CRISPR Activation Plasmid (m2) - sc-419225-ACT-2 from Santa Cruz Biotechnology
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ATF-1 Lentiviral Activation Particles (m) - sc-419225-LAC from Santa Cruz Biotechnology
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ATF-1 Lentiviral Activation Particles (m2) - sc-419225-LAC-2 from Santa Cruz Biotechnology
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ATF-1 siRNA (m) - sc-29755 from Santa Cruz Biotechnology
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ATF-1 shRNA Plasmid (m) - sc-29755-SH from Santa Cruz Biotechnology
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ATF-1 shRNA (m) Lentiviral Particles - sc-29755-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU095271 from Sigma-Aldrich
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MISSION® esiRNA - EMU093851 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN27134 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND27134 from Sigma-Aldrich
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ATF1 siRNA (Mouse) - CRM0281 from Cohesion Biosciences
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ATF1 - MBS828037 from MyBioSource
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shRNA set against Mouse ATF1 (NM_007497.3) - SHH241898 from Creative biogene
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shRNA set against Mouse Atf1(NM_007497.3) - SHG079417 from Creative biogene
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Mouse ATF1 siRNA - orb279757 from Biorbyt
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ATF1 shRNA Plasmid (Mouse) - CHM0281 from Cohesion Biosciences
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ATF1 miRNA 3'UTR clone - MiUTR1M-01771 from Creative biogene
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