| Gene Symbol |
Arap2
|
| Entrez Gene |
212285
|
| Alt Symbol |
Centd1, Gm148, mKIAA0580
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
|
| Other Description |
PARX protein|arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2|centaurin, delta 1|centaurin-delta-1|cnt-d1
|
| Swissprots |
Q8BZ05 Q80TX2 Q8C3T2 Q8VEL6
|
| Accessions |
EDL37698 Q8BZ05 AK037027 BAC29675 AK039153 BAC30258 AK041540 BAC30978 AK084988 BAC39331 AK122316 BAC65598 AK134702 AK136522 BAE23023 BC018234 AAH18234 XM_006503828 XP_006503891 XM_006503829 XP_006503892 XM_006503830 XP_006503893 XM_011240712 XP_011239014 NM_178407 NP_848494
|
| Function |
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Top Pathways |
Endocytosis
|