Gene Symbol | Arap2 |
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Entrez Gene | 212285 |
Alt Symbol | Centd1, Gm148, mKIAA0580 |
Species | Mouse |
Gene Type | protein-coding |
Description | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
Other Description | PARX protein|arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2|centaurin, delta 1|centaurin-delta-1|cnt-d1 |
Swissprots | Q8BZ05 Q80TX2 Q8C3T2 Q8VEL6 |
Accessions | EDL37698 Q8BZ05 AK037027 BAC29675 AK039153 BAC30258 AK041540 BAC30978 AK084988 BAC39331 AK122316 BAC65598 AK134702 AK136522 BAE23023 BC018234 AAH18234 XM_006503828 XP_006503891 XM_006503829 XP_006503892 XM_006503830 XP_006503893 XM_011240712 XP_011239014 NM_178407 NP_848494 |
Function | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Top Pathways | Endocytosis |
ARAP2 CRISPR/Cas9 KO Plasmid (m) - sc-431791 from Santa Cruz Biotechnology
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ARAP2 HDR Plasmid (m) - sc-431791-HDR from Santa Cruz Biotechnology
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ARAP2 Double Nickase Plasmid (m) - sc-431791-NIC from Santa Cruz Biotechnology
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ARAP2 Double Nickase Plasmid (m2) - sc-431791-NIC-2 from Santa Cruz Biotechnology
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ARAP2 CRISPR Activation Plasmid (m) - sc-431791-ACT from Santa Cruz Biotechnology
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ARAP2 CRISPR Activation Plasmid (m2) - sc-431791-ACT-2 from Santa Cruz Biotechnology
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ARAP2 Lentiviral Activation Particles (m) - sc-431791-LAC from Santa Cruz Biotechnology
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ARAP2 Lentiviral Activation Particles (m2) - sc-431791-LAC-2 from Santa Cruz Biotechnology
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ARAP2 siRNA (m) - sc-60199 from Santa Cruz Biotechnology
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ARAP2 shRNA Plasmid (m) - sc-60199-SH from Santa Cruz Biotechnology
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ARAP2 shRNA (m) Lentiviral Particles - sc-60199-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU061031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN26892 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND26892 from Sigma-Aldrich
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shRNA set against Mouse ARAP2 (NM_178407.3) - SHH239006 from Creative biogene
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