Kl

Gene Symbol	Kl
Entrez Gene	16591
Alt Symbol	alpha-kl
Species	Mouse
Gene Type	protein-coding
Description	klotho
Other Description	secreted form of Klotho protein
Swissprots	O70621 O70175 O35082 B2RR78
Accessions	BAA25308 BAA25309 EDL05885 EDL05886 O35082 AB005141 BAA23381 AB010088 BAA25307 AK134616 BAE22211 BC138258 AAI38259 BC138259 AAI38260 XM_006504917 XP_006504980 XM_006504951 XP_006505014 NM_013823 NP_038851
Function	May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 241 and 874, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1.
Subcellular Location	Klotho peptide: Secreted.
Tissue Specificity	Membrane-bound protein is present in distal renal tubules, inner ear, ependymal cells of brain choroid plexus, elongating spermatids and mature oocytes (at protein level). Soluble peptide is present in serum (100 pM) and cerebrospinal fluid. Expressed strongly in kidney, moderately in brain choroid plexus, and at low levels in pituitary, placenta, skeletal muscle, urinary bladder, aorta, pancreas, testis, ovary, colon, thyroid gland and adipocytes. {ECO:0000269|PubMed:10631108, ECO:0000269|PubMed:11411791, ECO:0000269|PubMed:12204354, ECO:0000269|PubMed:15135068, ECO:0000269|PubMed:15665504, ECO:0000269|PubMed:16123266, ECO:0000269|PubMed:9363890, ECO:0000269|PubMed:9537505}.
Top Pathways	Endocrine and other factor-regulated calcium reabsorption, Pentose and glucuronate interconversions, Starch and sucrose metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Klotho (KL), Mouse, ELISA Kit - SEH757Mu from ARP American Research Products Category ELISA Kit Prices $740.00 Sizes 96 t Sensitivity 5.1pg/mL Range 12.5-800pg/mL

Klotho, Kl, Mouse, ELISA Kit - E2253m from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 15.6-1000 pg/mL

Klotho, Mouse, ELISA Kit - CSB-E14362m from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.78 pg/ml Range 3.12 pg/ml-200 pg/ml

Klotho, Mouse, ELISA Kit - E03K0027 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 1.0 pg/mL Range 50-1000pg/mL,

Klotho (KL), Mouse, CLIA Kit - SCH757Mu from ARP American Research Products Category CLIA Kit Prices $864.00 Sizes 96 t Sensitivity 8.6pg/mL Range 25-1,600pg/mL

Mouse KL ELISA Kit - MK0034 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

klotho, ELISA Kit - MBS702609 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.78 pg/ml Range 3.12 pg/ml-200 pg/ml

Mouse Klotho ELISA Kit - CSB-E14362m from Cusabio Category ELISA Kit Sensitivity 0.78pg/ml Range 3.12 pg/ml-200 pg/ml

Mouse Klotho (KL) ELISA Kit - EKU05511 from Biomatik Category ELISA Kit Prices $756.00, $3,326.00, $6,048.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 1.25 pg/mL Range 3.12-200 pg/mL

Mouse Klotho(Klotho) ELISA Kit - E-EL-M2606 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 4.69 pg/mL Range 7.81~500 pg/mL

Mouse Klotho ELISA Kit - abx154296 from Abbexa Category ELISA Kit Sensitivity 5.1 pg/ml Range 12.5 pg/ml - 800 pg/ml

Mouse Klotho ELISA Kit - abx255095 from Abbexa Category ELISA Kit Range 15.6 pg/ml - 1000 pg/ml

Mouse Klotho CLIA Kit - abx190586 from Abbexa Category CLIA Kit Range 2.74 pg/ml - 2000 pg/ml

Klotho (KL), Mouse, ELISA Kit - DL-KL-Mu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Range 25-1,600 pg/mL

Mouse Klotho(Klotho) ELISA Kit - E-EL-M2606 from Elabscience Category ELISA Kit Sensitivity 4.69 pg/mL Range 7.81—500 pg/mL

Mouse Klotho ELISA kit - DEIA-XY9 from Creative Diagnostics Category ELISA Kit Sensitivity The minimum detectable dose of mouse klotho is typically less than 0.78 pg/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 3.12 pg/mL-200 pg/mL

Mouse KL ELISA Kit - abx574274 from Abbexa Category ELISA Kit Sensitivity 5.1 pg/ml Range 12.5 pg/ml - 800 pg/ml

Mouse Klotho (KL) ELISA Kit (CLIA) - EKU72567 from Biomatik Category ELISA Kit Prices $907.20, $3,991.68, $7,257.60 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 1.13pg/mL Range 2.74-2000pg/mL The standard curve concentrations used for the CLIA’s were 2000pg/mL, 666.67pg/mL, 222.22pg/mL, 74.07pg/mL, 24.69pg/mL, 8.23pg/mL, 2.74pg/mL

Mouse Klotho ELISA Kit - EKC37249 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,287.50 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.78pg/ml Range 3.12 pg/ml-200 pg/ml

Mouse Klotho ELISA Kit - EKE52449 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Range 15.6-1000 pg/mL

Kl - EKM1494 from Nordic BioSite Sensitivity 9.375pg/ml Range 15.6-1000pg/ml

KL ELISA Kit (Mouse) : 96 Wells (OKEH01597) - OKEH01597 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 10 pg/ml Range 15.6 - 1000 pg/mL

Mouse Klotho (KL) CLIA Kit - EKU09979 from Biomatik Category CLIA Kit Prices $907.00, $3,992.00, $7,258.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 1.13 pg/mL Range 31.25-2000 pg/mL

Mouse Kl ELISA Kit - E058112 from Biobool Category ELISA Kit Sensitivity < 9.4pg/ml

Mouse Klotho ELISA Kit - E058116 from Biobool Category ELISA Kit Sensitivity 4.688pg/mL

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