Kl

Gene Symbol	Kl
Entrez Gene	16591
Alt Symbol	alpha-kl
Species	Mouse
Gene Type	protein-coding
Description	klotho
Other Description	secreted form of Klotho protein
Swissprots	O70621 O70175 O35082 B2RR78
Accessions	BAA25308 BAA25309 EDL05885 EDL05886 O35082 AB005141 BAA23381 AB010088 BAA25307 AK134616 BAE22211 BC138258 AAI38259 BC138259 AAI38260 XM_006504917 XP_006504980 XM_006504951 XP_006505014 NM_013823 NP_038851
Function	May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 241 and 874, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1.
Subcellular Location	Klotho peptide: Secreted.
Tissue Specificity	Membrane-bound protein is present in distal renal tubules, inner ear, ependymal cells of brain choroid plexus, elongating spermatids and mature oocytes (at protein level). Soluble peptide is present in serum (100 pM) and cerebrospinal fluid. Expressed strongly in kidney, moderately in brain choroid plexus, and at low levels in pituitary, placenta, skeletal muscle, urinary bladder, aorta, pancreas, testis, ovary, colon, thyroid gland and adipocytes. {ECO:0000269|PubMed:10631108, ECO:0000269|PubMed:11411791, ECO:0000269|PubMed:12204354, ECO:0000269|PubMed:15135068, ECO:0000269|PubMed:15665504, ECO:0000269|PubMed:16123266, ECO:0000269|PubMed:9363890, ECO:0000269|PubMed:9537505}.
Top Pathways	Endocrine and other factor-regulated calcium reabsorption, Pentose and glucuronate interconversions, Starch and sucrose metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Klotho recombinant protein - GTX53837 from GeneTex Category Protein Prices $199.00 Sizes 20 μg Source CHO cells Species Mouse

Recombinant Mouse Klotho (aa 35-982), CF - 1819-KL-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Ala35-Lys982 (Arg948Lys), with a C-terminal 6-His tag

SCF protein (Mouse) - 30R-2979 from Fitzgerald Category Protein Prices $345.00 Sizes 10 µg Source E.coli Species Mouse

Stem Cell Factor protein (Mouse) - 30R-2193 from Fitzgerald Category Protein Prices $235.00 Sizes 5 µg Source E.coli Species Mouse

Mouse Klotho Protein - abx067661 from Abbexa Category Protein Source E.coli Species Mouse

Mouse Klotho Protein - abx067663 from Abbexa Category Protein Source E.coli Species Mouse

Klotho (alphaklotho), Human, Recombinant - 28-10200 from ARP American Research Products Category Protein Prices $99.00, $102.00, $199.00 Sizes 5 µg, 1 mg, 20 µg Source CHO cells Species Mouse

Klotho (KL), Mouse - 20-9306 from ARP American Research Products Category Protein Prices $449.00 Sizes 50 µg Source E.coli Species Mouse

Klotho (KL), Mouse - 20-9307 from ARP American Research Products Category Protein Prices $449.00 Sizes 50 µg Source E.coli Species Mouse

Recombinant Mouse Kl, His-tagged - Kl-362M from Creative Biomart Category Protein Source CHO cells Species Mouse

Recombinant Klotho (KL) - RPH757Mu01 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Klotho (KL) - RPH757Mu02 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Mouse Klotho(Kl) ,partial - CSB-YP012377MO CSB-EP012377MO CSB-BP012377MO CSB-MP012377MO from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Mouse

Klotho Protein (OPPB00099) - OPPB00099 from Aviva Systems Biology Category Protein Prices $215.00 Sizes 5 µg

Recombinant Mouse Klotho (aa 35-982) Protein, CF - 1819-KL from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Chinese Hamster Ovary cell line, CHO-derived Ala35-Lys982 (Arg948Lys), with a C-terminal 6-His tag Species Mouse

Klotho (KL) - RPU142432 from Biomatik Category Protein Prices $209.00, $418.00, $627.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Mouse

Klotho (KL) - RPU142434 from Biomatik Category Protein Prices $209.00, $418.00, $627.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Mouse

Recombinant Mouse KL Protein - KL-8667M from Creative Biomart Category Protein Source Mammalian Cells Species Mouse

Recombinant Klotho (KL) - RPU42432 from Biomatik Category Protein Prices $167.00, $342.00, $523.00, $653.60 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Mouse

Recombinant Klotho (KL) - RPU42434 from Biomatik Category Protein Prices $167.00, $342.00, $523.00, $653.60 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Mouse

KL Recombinant Protein (OPCD04678) - OPCD04678 from Aviva Systems Biology Category Protein Source E.coli Species Mouse

KL Recombinant Protein (OPCD04679) - OPCD04679 from Aviva Systems Biology Category Protein Source E.coli Species Mouse

Klotho (KL), Recombinant Protein - MBS2010881 from MyBioSource Category Protein Prices $170.00, $345.00, $535.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Mouse

Klotho (KL), Recombinant Protein - MBS2010008 from MyBioSource Category Protein Prices $170.00, $345.00, $535.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

Klotho (Kl), partial, Recombinant Protein - MBS1223957 from MyBioSource Category Protein Prices $1,305.00, $1,305.00, $1,525.00, $1,525.00, $2,115.00, $2,115.00, $2,570.00, $2,570.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Mouse

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