CD4

Gene Symbol	CD4
Entrez Gene	920
Alt Symbol	CD4mut
Species	Human
Gene Type	protein-coding
Description	CD4 molecule
Other Description	CD4 antigen (p55)|CD4 receptor|T-cell surface antigen T4/Leu-3|T-cell surface glycoprotein CD4
Swissprots	P01730 Q9UDE5 Q5U066 D3DUS5 B2R737 Q4ZGK2
Accessions	AAA16069 AAB51309 AAY22175 CAA60883 EAW88738 EAW88739 P01730 AK300052 BAG61861 AK303968 BAG64892 AK308344 AK310652 AK310677 AK310687 AK310750 AK311495 AK312828 BAG35684 AK315898 BAF98789 AK316461 BAH14832 AK316462 BAH14833 BC025782 AAH25782 BT019791 AAV38594 BT019811 AAV38614 BX378810 CA305950 DA384217 DA463597 DA619688 DA639898 DB123455 DQ892052 ABM82978 DQ895246 ABM86172 M12807 AAA35572 S79267 AAB35273 U40625 AAB02789 XM_011521039 XP_011519341 NM_000616 NP_000607 NM_001195014 NP_001181943 NM_001195015 NP_001181944 NM_001195016 NP_001181945 NM_001195017 NP_001181946 NR_036545
Function	Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:12517957}; Single-pass type I membrane protein {ECO:0000269|PubMed:12517957}. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
Top Pathways	Hematopoietic cell lineage, T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Primary immunodeficiency, Antigen processing and presentation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-CD4-cDNA-Clone - DC05535 from Abgent, a WuXi AppTec company Prices $618.30 Sizes 10 µg Species Human Accession BC025782

Human CD4 (NP_000607) VersaClone cDNA - RDC1130 from R&D Systems Prices $199.00 Sizes 10 µg Species Human

CD4 - MBS1272941 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC025782

Human CD4 Gene ORF cDNA clone in cloning vector - HG10400-M from Sino Biological Species Human

Human CD4 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10400-ACR from Sino Biological Species Human

Human CD4 Gene cDNA Clone (full-length ORF Clone) expression ready, untagged - HG10400-M-N from Sino Biological Species Human Accession NM_000616.3

Human CD4 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10400-ACG from Sino Biological Species Human

Human CD4 Gene ORF cDNA clone expression plasmid, N-His tag - HG10400-NH from Sino Biological Species Human

Human CD4 Gene cDNA Clone (full-length ORF Clone), expression ready, C-His-tagged - HG10400-CH from Sino Biological Species Human Accession NM_000616.3

Human CD4 Gene ORF cDNA clone expression plasmid - HG10400-UT from Sino Biological Species Human

Human CD4 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10400-NF from Sino Biological Species Human

Human CD4 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10400-NM from Sino Biological Species Human

Human CD4 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10400-CY from Sino Biological Species Human

Human CD4 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10400-CF from Sino Biological Species Human

Human CD4 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10400-NY from Sino Biological Species Human

Human CD4 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10400-CM from Sino Biological Species Human

Human CD4 ORF Clone(NM_001195015.2) - CDCR358436 from Creative biogene Species Human

Human CD4 ORF Clone (BC025782) - CDCS405796 from Creative biogene Species Human Accession P01730

Human CD4 ORF clone (NM_000616.3) - CDCB157463 from Creative biogene Species Human

Human CD4 Gene - orb90985 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

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