CD4

Gene Symbol	CD4
Entrez Gene	920
Alt Symbol	CD4mut
Species	Human
Gene Type	protein-coding
Description	CD4 molecule
Other Description	CD4 antigen (p55)|CD4 receptor|T-cell surface antigen T4/Leu-3|T-cell surface glycoprotein CD4
Swissprots	P01730 Q9UDE5 Q5U066 D3DUS5 B2R737 Q4ZGK2
Accessions	AAA16069 AAB51309 AAY22175 CAA60883 EAW88738 EAW88739 P01730 AK300052 BAG61861 AK303968 BAG64892 AK308344 AK310652 AK310677 AK310687 AK310750 AK311495 AK312828 BAG35684 AK315898 BAF98789 AK316461 BAH14832 AK316462 BAH14833 BC025782 AAH25782 BT019791 AAV38594 BT019811 AAV38614 BX378810 CA305950 DA384217 DA463597 DA619688 DA639898 DB123455 DQ892052 ABM82978 DQ895246 ABM86172 M12807 AAA35572 S79267 AAB35273 U40625 AAB02789 XM_011521039 XP_011519341 NM_000616 NP_000607 NM_001195014 NP_001181943 NM_001195015 NP_001181944 NM_001195016 NP_001181945 NM_001195017 NP_001181946 NR_036545
Function	Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:12517957}; Single-pass type I membrane protein {ECO:0000269|PubMed:12517957}. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
Top Pathways	Hematopoietic cell lineage, T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Primary immunodeficiency, Antigen processing and presentation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human CD4 protein fragment - ab167756 from Abcam Category Protein Prices $410.00 Sizes 200 µg Source HEK 293 cells Species Human

Active human CD4 protein fragment - ab111463 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human CD4 full length protein - ab39483 from Abcam Category Protein Prices $297.00 Sizes 10 µg Source E. coli Species Human

Human CD4 peptide - ab54699 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human CD4 protein fragment - ab83622 from Abcam Category Protein Prices $188.00 Sizes 5 µg Source E. coli Species Human

Human CD4 protein fragment - ab194048 from Abcam Category Protein Prices $155.00 Sizes 10 µg Source Mammalian Species Human

CD4 Blocking Peptide - LS-E3759 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD4 Antibody Blocking Peptide - LS-E21616 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD4 Recombinant Protein - H00000920-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

CD4 Recombinant Protein - H00000920-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CD4 Recombinant Protein - P4168 from Novus Biologicals Category Protein Prices $549.00 Sizes 10 µg Species Human

Recombinant Human CD4 Protein - NBP1-99435 from Novus Biologicals Category Protein Prices $190.00 Sizes 10 µg Source Baculovirus (Sf9 insect cells) Species Human

CD4 Recombinant Protein - H00000920-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

CD4 Peptide - P0495 from Novus Biologicals Category Peptide Species Human

CD4 Peptide - P0494 from Novus Biologicals Category Peptide Species Human

CD4 Recombinant Protein - P5116 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 50 µg Species Primate

CD4-Antibody-C-term-Blocking-Peptide - BP1496b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CD4-Antibody-N-term-Blocking-Peptide - BP1496a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CD4-Antibody-N-term-Blocking-Peptide - BP14942a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human sCD4 - 514-CD-050 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Lys26-Trp390

Recombinant Human sCD4, CF - 514-CD-050/CF from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Lys26-Trp390

Recombinant Cotton Rat sCD4, CF - 6676-CD-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Met1-Pro393, with a C-terminal 6-His tag

sCD4 Protein (OPPA00569) - OPPA00569 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source Baculovirus

Human CD4 (125-202) protein - orb80575 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Human CD4 (26-226) protein - orb80574 from Biorbyt Category Protein Prices $366.00, $400.00, $621.00 Sizes 5 μg, 2 μg, 10 μg Source E.coli

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