SETMAR

Gene Symbol SETMAR
Entrez Gene 6419
Alt Symbol HsMar1, METNASE, Mar1
Species Human
Gene Type protein-coding
Description SET domain and mariner transposase fusion gene
Other Description SET domain and mariner transposase fusion gene-containing protein|SET domain and mariner transposase fusion protein|histone-lysine N-methyltransferase SETMAR
Swissprots B4DY74 Q53H47 E7EN68 Q96F41 Q1G668 Q13579
Accessions AAC52010 ABC72087 EAW63903 EAW63904 EAW63905 Q53H47 AF054989 AAC09350 AK122967 AK222734 BAD96454 AK297865 BAG60194 AK302296 BAG63636 AK307537 AK311418 AY952295 AAY29570 BC008931 AAH08931 BC011635 AAH11635 BG479260 DC357038 U80776 AAC52012 XM_006713292 XP_006713355 XM_006713293 XP_006713356 XM_006713294 XP_006713357 XM_006713295 XP_006713358 XM_006713296 XP_006713359 XM_011534008 XP_011532310 NM_001243723 NP_001230652 NM_001276325 NP_001263254 NM_006515 NP_006506 NR_075073 NR_024022
Function Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates
Subcellular Location Nucleus {ECO:0000269|PubMed:18263876}. Chromosome {ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22231448}. Note=Recruited on damaged DNA at sites of double-strand break. {ECO:0000269|PubMed:18263876}.
Tissue Specificity Widely expressed, with highest expression in placenta and ovary and lowest expression in skeletal muscle. {ECO:0000269|PubMed:16332963}.
Top Pathways Lysine degradation

SETMAR (G-13) - sc-103211 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SETMAR (G-13): sc-103211. Western blot analysis of SETMAR expression in ES-2 whole cell lysate (A) and HL-60 nuclear extract (B).

SETMAR (S-12) - sc-103212 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SETMAR (H-67) - sc-367336 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-SETMAR antibody - ab129455 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SETMAR antibody (ab129455) at 0.4 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : 293T whole cell lysate at 50 µgLane 4 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-SETMAR antibody - ab3823 from Abcam

Prices $378.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ab3823 staining (2µg/ml) of Daudi lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 12 hours. Detected by western blot using chemiluminescence.

Anti-SETMAR antibody - ab110909 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab110909 at 1/50 dilution staining SETMAR in paraffin-embedded Human lung carcinoma tissue by Immunohistochemistry. The picture on the right is treated with the synthesized peptide.

Anti-SETMAR antibody - ab129468 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of SETMAR by Western Blot of Immunprecipitate. Anti-SETMAR antibody at 1µg/ml staining SETMAR in HeLa whole cell lysate immunoprecipitated using ab129468 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 30 seconds.

Anti-SETMAR antibody - ab167319 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-SETMAR antibody (ab167319) at 1 µg/mlLane 1 : SETMAR-transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.

Anti-SETMAR Antibody (aa1-50) - LS-C290273 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SETMAR Antibody (aa225-275) - LS-C290274 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SETMAR Antibody (aa350-400) - LS-C291443 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SETMAR Antibody (C-Terminus) - LS-C201591 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Jurkat. SETMAR antibody dilution 1.0 ug/ml.

Anti-SETMAR Antibody (C-Terminus) - LS-C345489 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of SETMR Antibody with human THP-1 Whole Cell lysate.

Anti-SETMAR Antibody - LS-C334913 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of HeLa cell using SETMAR antibody.

Anti-SETMAR Antibody (aa671-684) - LS-C55457 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody staining (2 ug/ml) of Daudi lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 12 hour. Detected by Western blot of chemiluminescence.

SETMAR Antibody - NBP1-97739 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunoprecipitation: SETMAR Antibody [NBP1-97739] - Samples: Whole cell lysate from HeLa (15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 ug ) and Jurkat (J; 50 ug ) cells. Antibodies: Affinity purified rabbit anti-Metnase antibody NBP1-97739 used for WB at 0.4 ug /ml (A) and 1 ug /ml (B) and used for IP at 6 ug /mg lysate. Metnase was also immunoprecipitated by rabbit anti-Metnase antibody NBP1-97740, which recognizes a downstream epitope. Detection: Chemiluminescence with exposure times of 30 seconds (A and B).

SETMAR Antibody - NB100-1142 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: SETMAR Antibody [NB100-1142] - Analysis of SETMAR in Daudi lysate using this antibody at 2 ug/ ml. Primary incubated for 12 hour. Detected using chemiluminescence.

SETMAR Antibody - H00006419-B01P from Novus Biologicals

Prices $349.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: SETMAR Antibody [H00006419-B01P] - analysis of SETMAR expression in transfected 293T cell line by SETMAR MaxPab polyclonal antibody. Lane 1: SETMAR transfected lysate (38.72 KDa). Lane 2: Non-transfected lysate.

SETMAR Antibody - NBP1-97740 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunoprecipitation: SETMAR Antibody [NBP1-97740] - Samples: Whole cell lysate from HeLa (15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 ug ) and Jurkat (J; 50 ug ) cells. Antibodies: Affinity purified rabbit anti-Metnase antibody NBP1-97739 used for WB at 0.4 ug /ml (A) and 1 ug /ml (B) and used for IP at 6 ug /mg lysate. Metnase was also immunoprecipitated by rabbit anti-Metnase antibody NBP1-97740, which recognizes a downstream epitope. Detection: Chemiluminescence with exposure times of 30 seconds (A and B).

Anti-SETMAR antibody produced in mouse - SAB1406427 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SETMAR: <B>Cat. No. SAB1406427</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~38.7 kDa using SETMAR transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-SETMAR antibody produced in goat - SAB2500932 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SETMAR: <B>Cat. No. SAB2500932</B>: staining (2 μg/mL) of Daudi lysate (RIPA buffer, 30 μg total protein per lane). Primary incubated for 12 hour. Detected by western blot using chemiluminescence.

SETMAR Antibody - C-terminal region (ARP51245_P050) - ARP51245_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SETMR Antibody - C-terminal region (ARP51246_P050) - ARP51246_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SETMAR-Antibody - AF1982a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF1982a staining (2 µg/ml) of Daudi lysate (RIPA buffer, 30 µg total protein per lane). Primary incubated for 12 hour. Detected by western blot using chemiluminescence.

SETMAR Antibody (OAAF04582) - OAAF04582 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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