SETMAR
| Gene Symbol | SETMAR |
|---|---|
| Entrez Gene | 6419 |
| Alt Symbol | HsMar1, METNASE, Mar1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | SET domain and mariner transposase fusion gene |
| Other Description | SET domain and mariner transposase fusion gene-containing protein|SET domain and mariner transposase fusion protein|histone-lysine N-methyltransferase SETMAR |
| Swissprots | B4DY74 Q53H47 E7EN68 Q96F41 Q1G668 Q13579 |
| Accessions | AAC52010 ABC72087 EAW63903 EAW63904 EAW63905 Q53H47 AF054989 AAC09350 AK122967 AK222734 BAD96454 AK297865 BAG60194 AK302296 BAG63636 AK307537 AK311418 AY952295 AAY29570 BC008931 AAH08931 BC011635 AAH11635 BG479260 DC357038 U80776 AAC52012 XM_006713292 XP_006713355 XM_006713293 XP_006713356 XM_006713294 XP_006713357 XM_006713295 XP_006713358 XM_006713296 XP_006713359 XM_011534008 XP_011532310 NM_001243723 NP_001230652 NM_001276325 NP_001263254 NM_006515 NP_006506 NR_075073 NR_024022 |
| Function | Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:18263876}. Chromosome {ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22231448}. Note=Recruited on damaged DNA at sites of double-strand break. {ECO:0000269|PubMed:18263876}. |
| Tissue Specificity | Widely expressed, with highest expression in placenta and ovary and lowest expression in skeletal muscle. {ECO:0000269|PubMed:16332963}. |
| Top Pathways | Lysine degradation |
SETMAR CRISPR/Cas9 KO Plasmid (h) - sc-417901 from Santa Cruz Biotechnology
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SETMAR HDR Plasmid (h) - sc-417901-HDR from Santa Cruz Biotechnology
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SETMAR Double Nickase Plasmid (h) - sc-417901-NIC from Santa Cruz Biotechnology
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SETMAR Double Nickase Plasmid (h2) - sc-417901-NIC-2 from Santa Cruz Biotechnology
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SETMAR CRISPR Activation Plasmid (h) - sc-417901-ACT from Santa Cruz Biotechnology
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SETMAR CRISPR Activation Plasmid (h2) - sc-417901-ACT-2 from Santa Cruz Biotechnology
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SETMAR Lentiviral Activation Particles (h) - sc-417901-LAC from Santa Cruz Biotechnology
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SETMAR Lentiviral Activation Particles (h2) - sc-417901-LAC-2 from Santa Cruz Biotechnology
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SETMAR siRNA (h) - sc-78354 from Santa Cruz Biotechnology
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SETMAR shRNA Plasmid (h) - sc-78354-SH from Santa Cruz Biotechnology
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SETMAR shRNA (h) Lentiviral Particles - sc-78354-V from Santa Cruz Biotechnology
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SETMAR RNAi - H00006419-R01 from Novus Biologicals
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MISSION® esiRNA - EHU017141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19176 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19176 from Sigma-Aldrich
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SETMAR siRNA (Human) - CRH4335 from Cohesion Biosciences
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SETMAR - MBS8202180 from MyBioSource
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shRNA set against Human SETMAR (NM_006515.3) - SHH405700 from Creative biogene
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Human SETMAR siRNA - orb264837 from Biorbyt
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SETMAR shRNA Plasmid (Human) - CHH4335 from Cohesion Biosciences
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SETMAR miRNA 3'UTR clone - MiUTR4H-TG07975 from Creative biogene
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