RPA2

Gene Symbol RPA2
Entrez Gene 6118
Alt Symbol REPA2, RP-A p32, RP-A p34, RPA32
Species Human
Gene Type protein-coding
Description replication protein A2, 32kDa
Other Description RF-A protein 2|replication factor A protein 2|replication protein A 32 kDa subunit|replication protein A 34 kDa subunit
Swissprots P15927 Q52II0 Q5TEJ5 Q5TEI9
Accessions AAX84514 EAX07724 P15927 AK298759 BAG60901 AK300691 BAG62374 AK312956 BAG35795 BC001630 AAH01630 BC012157 AAH12157 BC021257 AAH21257 BG107669 BQ006360 BX333932 CR450348 CAG29344 DB025488 DQ892352 ABM83278 DQ895821 ABM86747 J05249 AAA36560 XM_011541897 XP_011540199 NM_001286076 NP_001273005 NM_001297558 NP_001284487 NM_002946 NP_002937
Function As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interacti
Subcellular Location Nucleus. Nucleus, PML body. Note=Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner.
Top Pathways DNA replication, Mismatch repair, Homologous recombination, Nucleotide excision repair, Fanconi anemia pathway

Human-RPA2-cDNA-Clone - DC00754 from Abgent, a WuXi AppTec company

Prices $364.50
Sizes 10 µg
Species Human
Accession BC001630

RPA2 - MBS1266066 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC001630

Human NLK ORF clone(NM_002946.3) - CDCL185492 from Creative Biomart

Species Human
Accession NM_002946.3

Human RPA2 cDNA clone(NM_002946.3) - CDFH016498 from Creative Biomart

Species Human
Accession NM_002946.3

Human RPA2 cDNA clone(NM_002946.3) - CDFH016499 from Creative Biomart

Species Human
Accession NM_002946.3

Human RPA2 ORF clone(NM_002946.3) - CDCL186005 from Creative Biomart

Species Human
Accession NM_002946.3

Human RPA2 ORF Clone(NM_002946.3) - CDCR284480 from Creative Biomart

Species Human
Accession NM_002946.3

Human RPA2 ORF Clone(NM_002946.3) - CDCR284481 from Creative Biomart

Species Human
Accession NM_002946.3

Human RPA2 ORF Clone(NM_002946.3) - CDCR284482 from Creative Biomart

Species Human
Accession NM_002946.3
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