RPA2

Gene Symbol	RPA2
Entrez Gene	6118
Alt Symbol	REPA2, RP-A p32, RP-A p34, RPA32
Species	Human
Gene Type	protein-coding
Description	replication protein A2, 32kDa
Other Description	RF-A protein 2|replication factor A protein 2|replication protein A 32 kDa subunit|replication protein A 34 kDa subunit
Swissprots	P15927 Q52II0 Q5TEJ5 Q5TEI9
Accessions	AAX84514 EAX07724 P15927 AK298759 BAG60901 AK300691 BAG62374 AK312956 BAG35795 BC001630 AAH01630 BC012157 AAH12157 BC021257 AAH21257 BG107669 BQ006360 BX333932 CR450348 CAG29344 DB025488 DQ892352 ABM83278 DQ895821 ABM86747 J05249 AAA36560 XM_011541897 XP_011540199 NM_001286076 NP_001273005 NM_001297558 NP_001284487 NM_002946 NP_002937
Function	As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interacti
Subcellular Location	Nucleus. Nucleus, PML body. Note=Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner.
Top Pathways	DNA replication, Mismatch repair, Homologous recombination, Nucleotide excision repair, Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RPA32/RPA2 full length protein - ab40323 from Abcam Category Protein Source E. coli Species Human

Human RPA32/RPA2 full length protein - ab101216 from Abcam Category Protein Source E. coli Species Human

RPA2-Antibody-N-term--Blocking-Peptide - BP9115a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RPA2 Protein (OPPA02570) - OPPA02570 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human RPA2 protein - orb245089 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

RPA2 protein (His tag) - 80R-1553 from Fitzgerald Category Protein Prices $340.00 Sizes 50 µg Source E.coli

RPA2 (1-270, His-tag) - AR09732PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 250 µg Source E. coli Species Human

RPA2 (1-270, His-tag) - AR09732PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 50 µg Source E. coli Species Human

RPA2 - H00006118-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RPA2 - H00006118-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RPA2, 1-270aa, Human, His tag, E.coli - 01-RPA-2 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

RPA2 fusion protein - ag0690 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

RPA2 Human - PRPS-018 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human RPA2 Protein - BP002269-PRO-011 from Syd Labs Category Protein Prices $160.00, $5,200.00 Sizes 10 µg, 1 mg Source E. coli-derived. Species Human

RPA2, 1-270aa, Recombinant Protein - GWB-P1246K from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 50 μg, 250 μg Source E.coli Species Human

Recombinant Human RPA2, T7-tagged - RPA2-2983H from Creative Biomart Category Protein Source E.Coli.

Recombinant Human Replication Protein A2, 32kDa, His-tagged - RPA2-2852H from Creative Biomart Category Protein Source E.coli.

Recombinant Human RPA2, T7 -tagged - RPA2-30437TH from Creative Biomart Category Protein Source E. coli

Recombinant Human RPA2, His-tagged - RPA2-31146TH from Creative Biomart Category Protein Source E. coli

RPA2 - NKX-055 from Reagent Proteins Category Protein Prices $364.00, $2,898.00 Sizes 20.00 µg, 1 mg Source E.coli

RPA2 1-270aa - CMB-625 from Reagent Proteins Category Protein Prices $539.00, $1,099.00 Sizes 50.00 µg, 250.00 µg Source E.coli Species Human

RPA2 (A17) Peptide - BS1692P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant human Replication protein A 32 kDa subunit protein - CSB-EP015554h CSB-BP015554h CSB-MP015554h from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant human Replication protein A 32 kDa subunit protein - CSB-RP015554h from Cusabio Category Protein Species Human

Recombinant Human Replication protein A 32 kDa subunit(RPA2) - CSB-YP020089HU CSB-EP020089HU CSB-BP020089HU CSB-MP020089HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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