PRKAA1

Gene Symbol	PRKAA1
Entrez Gene	5562
Alt Symbol	AMPK, AMPKa1
Species	Human
Gene Type	protein-coding
Description	protein kinase, AMP-activated, alpha 1 catalytic subunit
Other Description	5'-AMP-activated protein kinase catalytic subunit alpha-1|5'-AMP-activated protein kinase, catalytic alpha-1 chain|ACACA kinase|AMP -activate kinase alpha 1 subunit|AMP-activated protein kinase, catalytic, alpha-1|AMPK alpha 1|AMPK subunit alpha-1|HMGCR kinase|acetyl-CoA carboxylase kinase|hydroxymethylglutaryl-CoA reductase kinase|tau-protein kinase PRKAA1
Swissprots	Q86VS1 Q5D0E1 O00286 Q9UNQ4 A8MTQ6 Q13131 B2R7E1
Accessions	EAW56000 EAW56001 Q13131 AB022017 BAA36547 AF100763 AAD43027 AK024252 AK307546 AK312947 BAG35788 BC012622 AAH12622 BC037303 AAH37303 BC048980 AAH48980 BQ049192 BQ716041 BX494823 CD512588 DB236105 JF432366 ADZ15583 U22456 AAA64850 Y12856 CAA73361 XM_006714482 XP_006714545 NM_006251 NP_006242 NM_206907 NP_996790
Function	Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphoryl
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15866171}. Nucleus {ECO:0000269|PubMed:15866171}. Note=In response to stress, recruited by p53/TP53 to specific promoters.
Top Pathways	Glucagon signaling pathway, AMPK signaling pathway, Oxytocin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PRKAA1-Over-expression-Lysate - LY11596a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

PRKAA1 293T Cell Transient Overexpression Lysate(Denatured) - H00005562-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

PRKAA1 overexpression lysate - LY404162 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

PRKAA1 overexpression lysate - LY416771 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

PRKAA1 overexpression lysate - LY430955 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

AMPK alpha 1 Overexpression Lysate (Native) - NBP2-10421 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

AMPK alpha 1 Overexpression Lysate (Denatured) - H00005562-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

AMPK alpha 1 Overexpression Lysate (Denatured) - H00005562-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human PRKAA1 Knockdown Stable Cell Line - CSC-DC012383 from Creative biogene Category Cell Line Species Human

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