KIT

Gene Symbol	KIT
Entrez Gene	3815
Alt Symbol	C-Kit, CD117, PBT, SCFR
Species	Human
Gene Type	protein-coding
Description	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Other Description	mast/stem cell growth factor receptor Kit|p145 c-kit|piebald trait protein|proto-oncogene c-Kit|proto-oncogene tyrosine-protein kinase Kit|soluble KIT variant 1|tyrosine-protein kinase Kit|v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
Swissprots	Q99662 P10721 D5LXN2 B5A956 Q6IQ28 F5H8F8 D5M931 Q9UM99
Accessions	AAB29301 AAB29529 AAC50968 AAC50969 ACI16424 ACI24886 CAA46771 CAA46772 CAA49159 CAJ15130 CAM35390 CAM91185 CAT16960 EAX05460 EAX05461 P10721 AJ438313 CAD27356 AK304031 BAG64945 BC071593 AAH71593 CN414753 DC376760 EU826594 ACF47630 GU983671 ADF36702 HM015525 ADF50068 HM015526 ADF50069 HM030712 ADF50070 HM030713 ADF50071 HM437240 ADN43071 X06182 CAA29548 XM_005265740 XP_005265797 XM_005265741 XP_005265798 XM_005265742 XP_005265799 NM_000222 NP_000213 NM_001093772 NP_001087241
Function	Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT p
Subcellular Location	Isoform 3: Cytoplasm. Note=Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head.
Tissue Specificity	Isoform 1 and isoform 2 are detected in spermatogonia and Leydig cells. Isoform 3 is detected in round spermatids, elongating spermatids and spermatozoa (at protein level). Widely expressed. Detected in the hematopoietic system, the gastrointestinal system, in melanocytes and in germ cells. {ECO:0000269|PubMed:20601678, ECO:0000269|PubMed:2448137}.
Top Pathways	Rap1 signaling pathway, Cytokine-cytokine receptor interaction, Central carbon metabolism in cancer, PI3K-Akt signaling pathway, Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Phospho-c-Kit (Tyr719) Sandwich ELISA Antibody Pair - 7299 from Cell Signaling Technology Category ELISA Kit Prices $459.00 Sizes 1 kit (Reagents for 4 x 96 well plates)

PathScan ® Phospho-c-Kit (panTyr) Sandwich ELISA Antibody Pair - 7294 from Cell Signaling Technology Category ELISA Kit Prices $459.00 Sizes 1 kit (Reagents for 4 x 96 well plates)

PathScan ® Phospho-c-Kit (panTyr) Sandwich ELISA Kit - 7231 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan® Total c-Kit Sandwich ELISA Kit - 7197 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® Phospho-c-Kit (Tyr719) Sandwich ELISA Kit - 7298 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

HTScan® c-Kit Kinase Assay Kit - 7755 from Cell Signaling Technology Category Assay Kit

c-Kit (CD117) Human ELISA Kit - ab45924 from Abcam Category ELISA Kit Prices $489.00, $734.00 Sizes 1 x 96 tests, 2 x 96 tests Sensitivity < 0.095 ng/ml Range 0.312 ng/ml - 10 ng/ml

Human C-Kit / CD117 ELISA Kit - LS-F5179 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.08 ng/ml Range 0.195 - 12.5 ng/ml (depending on sample type)

Mouse C-Kit / CD117 ELISA Kit - LS-F5503 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.063 ng/ml Range 0.156 - 10 ng/ml (depending on sample type)

Human C-Kit / CD117 ELISA Kit - LS-F2708 from LifeSpan Bioscience Category ELISA Kit Sensitivity 10 pg/ml Range 0.78 - 50 ng/ml (depending on sample type)

Human C-Kit / CD117 ELISA Kit - LS-F2972 from LifeSpan Bioscience Category ELISA Kit Sensitivity 20 pg/ml Range 0.78 - 50 ng/ml (depending on sample type)

Human C-Kit / CD117 ELISA Kit - LS-F360 from LifeSpan Bioscience Category ELISA Kit

Human C-Kit / CD117 ELISA Kit - LS-F841 from LifeSpan Bioscience Category ELISA Kit Range 32 - 2000 pg/ml (depending on sample type)

Mouse/Human Phospho-C-Kit / CD117 (Tyr936) Cell-Based ELISA Kit - LS-F1181 from LifeSpan Bioscience Category ELISA Kit

Mouse/Human Phospho-C-Kit / CD117 (Tyr703) Cell-Based ELISA Kit - LS-F1182 from LifeSpan Bioscience Category ELISA Kit

Mouse/Human/Rat Phospho-C-Kit / CD117 (Tyr721) Cell-Based ELISA Kit - LS-F1552 from LifeSpan Bioscience Category ELISA Kit

Mouse C-Kit / CD117 ELISA Kit - LS-F11882 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.051 ng/ml Range 0.156 - 10 ng/ml (depending on sample type)

Human C-Kit / CD117 ELISA Kit - LS-F11883 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.051 ng/ml Range 3.12 - 200 ng/ml (depending on sample type)

Phosphotyrosine KIT / Mast/stem Cell Growth Factor Receptor Kit ELISA Kit - RAB0992 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Human KIT / Mast/Stem Cell Growth Factor Receptor Kit ELISA Kit - RAB0731 from Sigma-Aldrich Category ELISA Kit Prices $633.00 Sizes 1 kt

KIT/SCFR BioAssay™ ELISA Kit, Human - 143942 from USBiological Life Science Category ELISA Kit Sensitivity < 10 pg/ml Range 0.78ng/ml-50ng/ml

Human Phospho-CD117/c-kit DuoSet IC Economy Pack - DYC3527E from R&D Systems Category ELISA Kit

Human Phospho-CD117/c-kit DuoSet IC ELISA - DYC3527-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00, $1,395.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates), 1 pack (for 15 Plates)

Human Phospho-CD117/c-kit DuoSet IC, 5 Plate - DYC3527-5 from R&D Systems Category ELISA Kit

Human CD117/c-kit Quantikine ELISA Kit - DSCR00 from R&D Systems Category ELISA Kit Prices $479.00 Sizes 1 kit Sensitivity 0.339 ng/mL Range 1.6 - 50 ng/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma)

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