ALOX15B

Gene Symbol ALOX15B
Entrez Gene 247
Alt Symbol 15-LOX-2
Species Human
Gene Type protein-coding
Description arachidonate 15-lipoxygenase, type B
Other Description 15-LOX-B|15S-lipoxygenase|arachidonate 15-lipoxygenase 2|arachidonate 15-lipoxygenase B|arachidonate 15-lipoxygenase type II|arachidonate 15-lipoxygenase, second type|arachidonate omega(6) lipoxygenase|linoleate 13-lipoxygenase 15-LOb
Swissprots Q8TEV5 Q8TEV3 D3DTR2 Q9UKM4 Q8TEV6 Q8TEV4 Q8IYQ2 O15296
Accessions AAD37786 CAC34521 EAW90097 EAW90098 EAW90099 EAW90100 EAW90101 EAW90102 O15296 AF468051 AAL76274 AF468052 AAL76275 AF468053 AAL76276 AF468054 AAL76277 AK292779 BAF85468 AK298095 BAG60380 AK300554 BAG62260 BC033294 BC035217 AAH35217 BC063647 AAH63647 BP327830 CA307212 CA405703 DQ891345 ABM82271 EU176579 ABW03380 U78294 AAB61706 NM_001039130 NP_001034219 NM_001039131 NP_001034220 NM_001141 NP_001132
Function Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)- HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells. {ECO:0000269|PubMed:10625675, ECO:0000269|PubMed:11839751, ECO:0000269|PubMed:12704195, ECO:0000269|PubMed:16112079, ECO:0000269|PubMed:18067895, ECO:0000269|PubMed:22912809, ECO:0000269|PubMed:24497644}.
Subcellular Location Isoform A: Nucleus. Note=Other isoforms are excluded from the nucleus.
Tissue Specificity Expressed in hair, prostate, lung, ovary, lymph node, spinal cord and cornea. {ECO:0000269|PubMed:10542053, ECO:0000269|PubMed:11350124, ECO:0000269|PubMed:9177185}.
Top Pathways Arachidonic acid metabolism

15-LO2 CRISPR/Cas9 KO Plasmid (h) - sc-404699 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

15-LO2 HDR Plasmid (h) - sc-404699-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

15-LO2 Double Nickase Plasmid (h) - sc-404699-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

15-LO2 Double Nickase Plasmid (h2) - sc-404699-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

15-LO2 CRISPR Activation Plasmid (h) - sc-404699-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

15-LO2 CRISPR Activation Plasmid (h2) - sc-404699-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

15-LO2 Lentiviral Activation Particles (h) - sc-404699-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

15-LO2 Lentiviral Activation Particles (h2) - sc-404699-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

15-LO2 siRNA (h) - sc-45626 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

15-LO2 shRNA Plasmid (h) - sc-45626-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

15-LO2 shRNA (h) Lentiviral Particles - sc-45626-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

15-Lipoxygenase 2 RNAi - H00000247-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU063701 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3080 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3080 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04511 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04511

ALOX15B siRNA (Human) - CRH0171 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ALOX15B - MBS8229322 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ALOX15B (NM_001141.2) - SHH235378 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ALOX15B(NM_001039131.1) - SHG032075 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ALOX15B(NM_001039130.1) - SHG032093 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ALOX15B(NM_001141.2) - SHG032130 from Creative biogene

Category siRNA
Species Reactivities Human

ALOX15B shRNA Plasmid (Human) - CHH0171 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ALOX15B miRNA 3'UTR clone - MiUTR1H-00314 from Creative biogene

Species Reactivities Human

ALOX15B miRNA 3'UTR clone - MiUTR1H-00315 from Creative biogene

Species Reactivities Human
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