ALOX15B

Gene Symbol ALOX15B
Entrez Gene 247
Alt Symbol 15-LOX-2
Species Human
Gene Type protein-coding
Description arachidonate 15-lipoxygenase, type B
Other Description 15-LOX-B|15S-lipoxygenase|arachidonate 15-lipoxygenase 2|arachidonate 15-lipoxygenase B|arachidonate 15-lipoxygenase type II|arachidonate 15-lipoxygenase, second type|arachidonate omega(6) lipoxygenase|linoleate 13-lipoxygenase 15-LOb
Swissprots Q8TEV5 Q8TEV3 D3DTR2 Q9UKM4 Q8TEV6 Q8TEV4 Q8IYQ2 O15296
Accessions AAD37786 CAC34521 EAW90097 EAW90098 EAW90099 EAW90100 EAW90101 EAW90102 O15296 AF468051 AAL76274 AF468052 AAL76275 AF468053 AAL76276 AF468054 AAL76277 AK292779 BAF85468 AK298095 BAG60380 AK300554 BAG62260 BC033294 BC035217 AAH35217 BC063647 AAH63647 BP327830 CA307212 CA405703 DQ891345 ABM82271 EU176579 ABW03380 U78294 AAB61706 NM_001039130 NP_001034219 NM_001039131 NP_001034220 NM_001141 NP_001132
Function Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)- HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells. {ECO:0000269|PubMed:10625675, ECO:0000269|PubMed:11839751, ECO:0000269|PubMed:12704195, ECO:0000269|PubMed:16112079, ECO:0000269|PubMed:18067895, ECO:0000269|PubMed:22912809, ECO:0000269|PubMed:24497644}.
Subcellular Location Isoform A: Nucleus. Note=Other isoforms are excluded from the nucleus.
Tissue Specificity Expressed in hair, prostate, lung, ovary, lymph node, spinal cord and cornea. {ECO:0000269|PubMed:10542053, ECO:0000269|PubMed:11350124, ECO:0000269|PubMed:9177185}.
Top Pathways Arachidonic acid metabolism

15-LO2 (D-6) - sc-376871 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
15-LO2 (D-6): sc-376871. Western blot analysis of 15-LO2 expression in non-transfected: sc-117752 (A) and human 15-LO2 transfected: sc-113863 (B) 293T whole cell lysates.

15-LO2 (D-20) - sc-46048 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
15-LO2 (D-20): sc-46048. Western blot analysis of 15-LO2 expression in non-transfected: sc-117752 (A) and human 15-LO2 transfected: sc-113863 (B) 293T whole cell lysates.

15-LO2 (D-9) - sc-271290 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
15-LO2 (D-9): sc-271290. Western blot analysis of 15-LO2 expression in non-transfected: sc-117752 (A) and human 15-LO2 transfected: sc-113863 (B) 293T whole cell lysates.

15-LO2 (E-13) - sc-46049 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
15-LO2 (E-13): sc-46049. Western blot analysis of 15-LO2 expression in non-transfected: sc-117752 (A) and human 15-LO2 transfected: sc-113863 (B) 293T whole cell lysates.

15-LO2 (H-55) - sc-67142 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
15-LO2 (H-55): sc-67142. Western blot analysis of 15-LO2 expression in non-transfected: sc-117752 (A) and human 15-LO2 transfected: sc-113863 (B) 293T whole cell lysates.

15-LO2 (H-6) - sc-166387 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
15-LO2 (H-6): sc-166387. Western blot analysis of 15-LO2 expression in non-transfected: sc-117752 (A) and human 15-LO2 transfected: sc-113863 (B) 293T whole cell lysates.

15-LO2 (K-20) - sc-46050 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
15-LO2 (K-20): sc-46050. Western blot analysis of 15-LO2 expression in non-transfected 293T: sc-117752 (A), human 15-LO2 transfected 293T: sc-113863 (B) and HeLa (C) whole cell lysates.

15-LO2 (M-50) - sc-67143 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
15-LO2 (M-50): sc-67143. Western blot analysis of 15-LO2 expression in non-transfected: sc-117752 (A) and human 15-LO2 transfected: sc-113863 (B) 293T whole cell lysates.

Anti-15 Lipoxygenase 2 antibody - ab113488 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-15 Lipoxygenase 2 antibody (ab113488) at 1/500 dilution + IB8 cell lysate

Anti-15 Lipoxygenase 2 antibody - ab23691 from Abcam

Prices $394.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-15 Lipoxygenase 2 antibody (ab23691) at 4 µg/mlLane 1 : Rabbit reticulocyte lysate (30 µg).Lane 2 : Human prostate homogenate (30 µg).

Anti-ALOX15B / 15-LOX-2 Antibody (aa161-179) IHC-plus™ - LS-B1588 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ALOX15B / 15 Lipoxygenase 2 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1588 concentration 5 ug/ml.

Anti-ALOX15B / 15-LOX-2 Antibody - LS-C25232 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ALOX15B / 15-LOX-2 Antibody (aa585-634) - LS-C31955 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Jurkat Cell Lysate

Anti-ALOX15B / 15-LOX-2 Antibody (N-Terminus) - LS-C80468 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-ALOX15B / 15-LOX-2 Antibody (aa254-303) - LS-C80470 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal brain lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-ALOX15B / 15-LOX-2 Antibody (aa401-450) - LS-C117046 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ALOX15B / 15 Lipoxygenase 2 antibody LS-C117046 Western blot of HepG2 cell lysate.

Anti-ALOX15B / 15-LOX-2 Antibody (aa253-490) - LS-C314766 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant ALOX15B / 15 Lipoxygenase 2.

Anti-ALOX15B / 15-LOX-2 Antibody - LS-C346124 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence blot of HeLa cell using ALOX15B antibody. Blue: DAPI for nuclear staining.

Anti-ALOX15B / 15-LOX-2 Antibody (aa597-627) - LS-C156290 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human skin tissue reacted with ALOX15B Antibody ,which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-ALOX15B / 15-LOX-2 Antibody (clone 4A7) - LS-C196648 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4A7
Immunofluorescence of monoclonal antibody to ALOX15B on HeLa cell . [antibody concentration 10 ug/ml]

Anti-ALOX15B / 15-LOX-2 Antibody (aa21-262) - LS-C178528 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

15-Lipoxygenase 2 Antibody - NBP1-55145 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: 15-Lipoxygenase 2 Antibody [NBP1-55145] - HepG2 cell lysate, concentration 0.2-1 ug/ml.

15-Lipoxygenase 2 Antibody (4A7) - H00000247-M05 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4A7
Immunocytochemistry/Immunofluorescence: 15-Lipoxygenase 2 Antibody (4A7) [H00000247-M05] - Analysis of monoclonal antibody to ALOX15B on HeLa cell. Antibody concentration 10 ug/ml

ALOX15B Polyclonal Antibody - bs-6335R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Lane 1: mouse brain lysates Lane 2: mouse heart lysates probed with Anti ALOX15B/15 Lipoxygenase 2 Polyclonal Antibody, Unconjugated (bs-6335R) at 1:200 in 4˚C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:3000 90min in 37˚C. Predicted band 74kD. Observed band size: 74kD.

Monoclonal Anti-ALOX15B antibody produced in mouse - SAB1402114 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4A7
<B>ELISA</B><BR/>Monoclonal Anti-ALOX15B, antibody produced in mouse, clone 4A7, purified immunoglobulin: <B>Cat. No. SAB1402114</B>: Detection limit for recombinant GST tagged ALOX15B is approximately 10 ng/mL.
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