| Gene Symbol |
FCER1A
|
| Entrez Gene |
2205
|
| Alt Symbol |
FCE1A, FcERI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
|
| Other Description |
Fc IgE receptor, alpha polypeptide|Fc epsilon RI alpha-chain|Fc-epsilon RI-alpha|high affinity immunoglobulin epsilon receptor alpha-subunit|high affinity immunoglobulin epsilon receptor subunit alpha|igE Fc receptor subunit alpha|immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide
|
| Swissprots |
P12319
|
| Accessions |
AAA16115 BAB84120 CAA01564 CAA82702 CAN36268 EAW52789 P12319 BC005912 AAH05912 BC015185 BC015195 AAH15195 DQ893131 ABM84057 DQ896411 ABM87410 DQ896467 ABM87466 J03605 AAA36204 X06948 CAA30025 NM_002001 NP_001992
|
| Function |
Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein.
|
| Top Pathways |
Fc epsilon RI signaling pathway, Asthma, Sphingolipid signaling pathway
|
![Western Blot: Fc epsilon RI Overexpression Lysate (Adult Normal) [NBL1-10650] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Fc epsilon RI.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4728_Fc%2520epsilon%2520RI%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10650-img0002.jpg)