| Gene Symbol |
Mtor
|
| Entrez Gene |
56717
|
| Alt Symbol |
2610315D21Rik, AI327068, FRAP, FRAP2, Frap1, RAFT1, RAPT1, flat
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
mechanistic target of rapamycin (serine/threonine kinase)
|
| Other Description |
FK506 binding protein 12-rapamycin associated protein 1|FK506-binding protein 12-rapamycin complex-associated protein 1|FKBP-rapamycin associated protein (FRAP)|FKBP-rapamycin-associated protein FRAP|FKBP12-rapamycin complex-associated protein|angiopoietin-like factor CDT6|mammalian target of rapamycin|rapamycin target protein 1|serine/threonine-protein kinase mTOR
|
| Swissprots |
Q9JLN9 Q9CST1 Q811J5 Q2KHT0
|
| Accessions |
AAK38597 EDL14819 EDL14820 Q9JLN9 AF152838 AAF73196 AK012031 BAB27985 AK036004 AK143381 AK158715 AK172584 BAE43081 BC021454 BC043920 AAH43920 BC112904 AAI12905 CJ130100 XM_006539077 XP_006539140 NM_020009 NP_064393
|
| Function |
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through R
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome {ECO:0000250}. Cytoplasm. Nucleus, PML body. Note=Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia. Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB (By similarity). {ECO:0000250}.
|
| Top Pathways |
Insulin signaling pathway, Proteoglycans in cancer, Choline metabolism in cancer, Central carbon metabolism in cancer, Acute myeloid leukemia
|