Mtor

Gene Symbol	Mtor
Entrez Gene	56717
Alt Symbol	2610315D21Rik, AI327068, FRAP, FRAP2, Frap1, RAFT1, RAPT1, flat
Species	Mouse
Gene Type	protein-coding
Description	mechanistic target of rapamycin (serine/threonine kinase)
Other Description	FK506 binding protein 12-rapamycin associated protein 1|FK506-binding protein 12-rapamycin complex-associated protein 1|FKBP-rapamycin associated protein (FRAP)|FKBP-rapamycin-associated protein FRAP|FKBP12-rapamycin complex-associated protein|angiopoietin-like factor CDT6|mammalian target of rapamycin|rapamycin target protein 1|serine/threonine-protein kinase mTOR
Swissprots	Q9JLN9 Q9CST1 Q811J5 Q2KHT0
Accessions	AAK38597 EDL14819 EDL14820 Q9JLN9 AF152838 AAF73196 AK012031 BAB27985 AK036004 AK143381 AK158715 AK172584 BAE43081 BC021454 BC043920 AAH43920 BC112904 AAI12905 CJ130100 XM_006539077 XP_006539140 NM_020009 NP_064393
Function	Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through R
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome {ECO:0000250}. Cytoplasm. Nucleus, PML body. Note=Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia. Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB (By similarity). {ECO:0000250}.
Top Pathways	Insulin signaling pathway, Proteoglycans in cancer, Choline metabolism in cancer, Central carbon metabolism in cancer, Acute myeloid leukemia

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

SignalSilence ® mTOR siRNA II (Mouse Specific) - 6342 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Mouse

SignalSilence ® mTOR siRNA I (Mouse Specific) - 6332 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Mouse

mTOR CRISPR/Cas9 KO Plasmid (m) - sc-425273 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

mTOR HDR Plasmid (m) - sc-425273-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

mTOR Double Nickase Plasmid (m) - sc-425273-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

mTOR Double Nickase Plasmid (m2) - sc-425273-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

mTOR CRISPR Activation Plasmid (m) - sc-425273-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

mTOR CRISPR Activation Plasmid (m2) - sc-425273-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

mTOR Lentiviral Activation Particles (m) - sc-425273-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

mTOR Lentiviral Activation Particles (m2) - sc-425273-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

mTOR siRNA (m) - sc-35410 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

mTOR shRNA Plasmid (m) - sc-35410-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

mTOR shRNA (m) Lentiviral Particles - sc-35410-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

MISSION® esiRNA - EMU047451 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN35964 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND35964 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MTOR siRNA (Mouse) - CRM5902 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

shRNA set against Mouse MTOR (NM_020009.2) - SHH346608 from Creative biogene Category siRNA Species Reactivities Mouse

Mouse MTOR siRNA - orb285378 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

MTOR shRNA Plasmid (Mouse) - CHM5902 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Mouse

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