KCNH1

Gene Symbol KCNH1
Entrez Gene 3756
Alt Symbol EAG, EAG1, Kv10.1, TMBTS, h-eag
Species Human
Gene Type protein-coding
Description potassium channel, voltage gated eag related subfamily H, member 1
Other Description EAG channel 1|ether-a-go-go potassium channel 1|ether-a-go-go, Drosophila, homolog of|hEAG1|potassium voltage-gated channel subfamily H member 1|potassium voltage-gated channel, subfamily H (eag-related), member 1|voltage-gated potassium channel subunit Kv10.1
Swissprots O76035 Q14CL3 O95259 B1AQ26
Accessions CCQ43886 EAW93424 EAW93425 O95259 AF078741 AAC68668 AF078742 AAC68669 AJ001366 CAA04700 AK127526 BC113709 AAI13710 BC143599 AAI43600 XM_011509514 XP_011507816 NM_002238 NP_002229 NM_172362 NP_758872
Function Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:22732247). Channel properties may be modulated by subunit assembly, but not by cyclic nucleotides (By similarity). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642). {ECO:0000250|UniProtKB:Q60603, ECO:0000269|PubMed:22732247, ECO:0000269|PubMed:23881642, ECO:0000269|PubMed:9738473}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:21559285, ECO:0000269|PubMed:22732247, ECO:0000269|PubMed:22841712}; Multi- pass membrane protein {ECO:0000269|PubMed:21559285}. Nucleus inner membrane {ECO:0000269|PubMed:21559285}; Multi-pass membrane protein {ECO:0000269|PubMed:21559285}. Early endosome membrane {ECO:0000269|PubMed:22841712}. Note=Perinuclear KCNH1 is located to NPC-free islands.
Tissue Specificity Highly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells.

KCNH1 (C-11) - sc-398585 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
KCNH1 (C-11): sc-398585. Western blot analysis of KCNH1 expression in SH-SY5Y (A), Sol8 (B), L8 (C), SK-N-MC (D) and H4 (E) whole cell lysates.

KCNH1 (T-13) - sc-161766 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
KCNH1 (T-13): sc-161766. Immunoperoxidase staining of formalin fixed, paraffin-embedded human hippocampus tissue showing cytoplasmic staining of neuronal cells and glial cells.

Anti-KCNH1 antibody - ab86204 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-KCNH1 antibody - ab93490 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-KCNH1 antibody - ab137007 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-KCNH1 antibody (ab137007) at 1/500 dilution + COLO205 cell lysate at 30 µg

Anti-KCNH1 antibody [EPR3802] - ab108537 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3802
All lanes : Anti-KCNH1 antibody [EPR3802] (ab108537) at 1/1000 dilutionLane 1 : SH-SY5Y cell lysateLane 2 : MCF7 cell lysateLane 3 : A673 cell lysate Lysates/proteins at 10 µg per lane.

Anti-Kv10.1 / KCNH1 Antibody (aa400-450, DY650) - LS-C143285 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Kv10.1 / KCNH1 Antibody (aa400-450, Biotin) - LS-C143284 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Kv10.1 / KCNH1 Antibody (aa400-450, HRP) - LS-C143287 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Kv10.1 / KCNH1 Antibody (aa400-450, DY488) - LS-C143286 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Kv10.1 / KCNH1 Antibody (aa720-769) - LS-C291356 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Kv10.1 / KCNH1 Antibody (aa703-752) - LS-C292116 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Kv10.1 / KCNH1 Antibody (aa400-450, DY550) - LS-C143288 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Kv10.1 / KCNH1 Antibody (aa762-807) - LS-C313803 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Kv10.1 / KCNH1 Antibody (Internal, clone EPR3802) - LS-C137744 from LifeSpan Bioscience

Prices $450.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3802
Western blot analysis on (A) SH-SY5Y, (B) MCF-7 and (C) A673 cell lysates using anti-KCNH1 antibody.

Anti-Kv10.1 / KCNH1 Antibody - LS-C335693 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using KCNH1 antibody.

Anti-Kv10.1 / KCNH1 Antibody (aa400-450) - LS-C143283 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
KCNH1 Antibody - Western blot of KCNH1 expression in rat brain lysate.

KCNH1 Antibody - NBP1-84935 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: KCNH1 Antibody [NBP1-84935] - Staining of human lateral ventricle shows moderate cytoplasmic and nucleolar positivity in neuronal cells.

KCNH1 Antibody - H00003756-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: KCNH1 Antibody [H00003756-A01] - KCNH1 polyclonal antibody (A01), Lot # 061110JCS1 Western Blot analysis of KCNH1 expression in SJCRH30 ( Cat # L027V1 ).

KCNH1 Polyclonal Antibody - bs-2424R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNH1 antibody produced in rabbit - HPA019445 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-KCNH1: <B>Cat. No. HPA019445</B>: Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity in neuronal cells.

Anti-Potassium Channel Kv10.1 (EAG-1) antibody produced in rabbit - P0999 from Sigma-Aldrich

Prices $204.50, $563.00
Sizes 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunocytochemistry</B><BR/>Anti-K<SUB>v</SUB>10.1 (EAG-1): <B>Cat. No. P0999</B>: Immunocytochemical staining of pA. Cells were stained with Anti-K<SUB>v</SUB>10.1 (EAG-1) antibody, (1:200) followed by Goat Anti-Rabbit-AlexaFluor-555 secondary antibody (red). B. Nuclei were visualized with the cell-permeable dye Hoechst 33342 (blue). C. Merged image of panels A and B.

Kv101-Antibody - AP51821 from Abgent, a WuXi AppTec company

Prices $295.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Kv10.1 Antibody at 1:1000 dilution + HeLa whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 111 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

KCNH1 antibody [EPR3802] - GTX62398 from GeneTex

Host Rabbit
Clonality Monoclonal
Clone EPR3802
Anti-KCNH1 antibody [EPR3802] used in Western blot. GTX62398

KCNH1 antibody [N3C2], Internal - GTX109041 from GeneTex

Host Rabbit
Clonality Polyclonal
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