birA
| Gene Symbol | birA |
|---|---|
| Entrez Gene | 948469 |
| Alt Symbol | ECK3965, JW3941, bioR, dhbB |
| Species | Escherichia coli |
| Gene Type | protein-coding |
| Description | bifunctional biotin-[acetylCoA carboxylase] holoenzyme synthetase/ DNA-binding transcriptional repressor, bio-5'-AMP-binding |
| Other Description | - |
| Swissprots | Q2M8R4 P06709 |
| Accessions | AAC43075 AAC76951 NP_418404 |
| Function | Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. {ECO:0000255|HAMAP- Rule:MF_00978, ECO:0000269|PubMed:12527300, ECO:0000269|PubMed:2667763, ECO:0000269|PubMed:6129246, ECO:0000269|PubMed:8003500}. |
| Top Pathways | Biotin metabolism |
Anti-ECbirA / BirA Antibody - LS-C77044 from LifeSpan Bioscience
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BirA Antibody - NB600-1098 from Novus Biologicals
![Western Blot: BirA Antibody [NB600-1098] - Western Blot: E coli-derived fusion protein as test antigen. Affi-anti- BirA IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development. ( anti-birA )](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_1/23813_p_44b7df42dd9b8.jpg)
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Anti-BirA Antibody - LS-C483764 from LifeSpan Bioscience
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Anti-BirA Antibody - LS-C483762 from LifeSpan Bioscience
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