Gene Symbol | birA |
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Entrez Gene | 948469 |
Alt Symbol | ECK3965, JW3941, bioR, dhbB |
Species | Escherichia coli |
Gene Type | protein-coding |
Description | bifunctional biotin-[acetylCoA carboxylase] holoenzyme synthetase/ DNA-binding transcriptional repressor, bio-5'-AMP-binding |
Other Description | - |
Swissprots | Q2M8R4 P06709 |
Accessions | AAC43075 AAC76951 NP_418404 |
Function | Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. {ECO:0000255|HAMAP- Rule:MF_00978, ECO:0000269|PubMed:12527300, ECO:0000269|PubMed:2667763, ECO:0000269|PubMed:6129246, ECO:0000269|PubMed:8003500}. |
Top Pathways | Biotin metabolism |
Active E. coli BirA full length protein - ab135015 from Abcam
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E. coli BirA full length protein - ab198449 from Abcam
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E. coli BirA full length protein - ab198454 from Abcam
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E.coli BirA protein (MBP Tag) - orb138259 from Biorbyt
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Recombinant Escherichia coli Bifunctional protein BirA(birA) - CSB-YP361925ENV CSB-EP361925ENV CSB-BP361925ENV CSB-MP361925ENV from Cusabio
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Bifunctional protein BirA (birA), Recombinant Protein - MBS1053823 from MyBioSource
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