PPP1CC

Gene Symbol	PPP1CC
Entrez Gene	5501
Alt Symbol	PP-1G, PP1C, PPP1G
Species	Human
Gene Type	protein-coding
Description	protein phosphatase 1, catalytic subunit, gamma isozyme
Other Description	protein phosphatase 1, catalytic subunit, gamma isoform|protein phosphatase 1C catalytic subunit|serine/threonine phosphatase 1 gamma|serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Swissprots	P36873
Accessions	BAA82664 EAW97938 EAW97939 EAW97940 P36873 AA781342 AK091841 AK297882 BAG60205 AW575661 BC014073 AAH14073 DA472620 DA514523 EU831993 ACE87434 EU832086 ACE86748 JF432841 ADZ16058 L07395 AAA19823 X74008 CAA52169 XM_011538504 XP_011536806 XM_011538505 XP_011536807 NM_001244974 NP_001231903 NM_002710 NP_002701
Function	Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue
Subcellular Location	Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Chromosome, centromere, kinetochore. Cleavage furrow. Midbody. Mitochondrion. Note=Colocalizes with SPZ1 in the nucleus (By similarity). Colocalizes with URI1 at mitochondrion. Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments. Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles. Shows a dynamic targeting to specific sites throughout the cell cycle. Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis. Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase. Also accumulates at the cleavage furrow and midbody by telophase. {ECO:0000250}.
Top Pathways	Amphetamine addiction, cGMP-PKG signaling pathway, Oxytocin signaling pathway, cAMP signaling pathway, Inflammatory mediator regulation of TRP channels

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PP1C gamma full length protein - ab114828 from Abcam Category Protein Source Wheat germ Species Human

Human PP1C gamma full length protein - ab126675 from Abcam Category Protein Species Human

Human PP1C gamma full length protein - ab152022 from Abcam Category Protein Source E. coli Species Human

PPP1CC / PP1 Gamma Antibody Blocking Peptide - LS-E4619 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPP1CC / PP1 Gamma Antibody Blocking Peptide - LS-E23577 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPP1CC / PP1 Gamma Antibody Blocking Peptide - LS-E9575 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPP1CC / PP1 Gamma Antibody Blocking Peptide - LS-E9576 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Protein Phosphatase 1C gamma Recombinant Protein - H00005501-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Protein Phosphatase 1C gamma Protein - NBP1-98976 from Novus Biologicals Category Protein Prices $269.00 Sizes 20 µg Source E. coli Species Human

Protein Phosphatase 1C gamma Peptide - P3265 from Novus Biologicals Category Peptide Species Human

Protein Phosphatase 1C gamma Peptide - P3264 from Novus Biologicals Category Peptide Species Human

PPP1CC-Antibody-C-term-Blocking-Peptide - BP16979b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PP1C-gamma-PPP1CC-Antibody-C-term-Blocking-peptide - BP8432b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PP1C-gamma-PPP1CC-Antibody-N-term-Blocking-peptide - BP8432a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human PPP1CC protein - orb49642 from Biorbyt Category Protein Prices $408.00, $595.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human PPP1CC protein - orb169069 from Biorbyt Category Protein Prices $170.00, $289.00, $1,139.00 Sizes 2 μg, 10 μg, 100 μg Species Human

PPP1CC protein (His tag) - 80R-2291 from Fitzgerald Category Protein Prices $270.00 Sizes 20 µg Source E.coli

PPP1CC (1-323, His-tag) - AR50375PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 100 µg Source E. coli Species Human

PPP1CC (1-323, His-tag) - AR50375PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 20 µg Source E. coli Species Human

PPP1CC - H00005501-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PPP1CC - H00005501-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PP-1G, PPP1CC, Human, Recombinant - 19-CE80 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source E. coli Species Human

PPP1CC, 1-323aa, Human, His tag, E.coli - 01-P1551 from ARP American Research Products Category Protein Prices $139.00, $369.00, $849.00 Sizes 5 µg, 20 µg, 100 µg Species Human

PPP1CC Recombinant Protein - XW-RP3205 from ProSci Category Protein Prices $475.00 Sizes 20 µg Source E. coli Species Human

PPP1CC fusion protein - ag1550 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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