| Gene Symbol | PPP1CC |
|---|---|
| Entrez Gene | 5501 |
| Alt Symbol | PP-1G, PP1C, PPP1G |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein phosphatase 1, catalytic subunit, gamma isozyme |
| Other Description | protein phosphatase 1, catalytic subunit, gamma isoform|protein phosphatase 1C catalytic subunit|serine/threonine phosphatase 1 gamma|serine/threonine-protein phosphatase PP1-gamma catalytic subunit |
| Swissprots | P36873 |
| Accessions | BAA82664 EAW97938 EAW97939 EAW97940 P36873 AA781342 AK091841 AK297882 BAG60205 AW575661 BC014073 AAH14073 DA472620 DA514523 EU831993 ACE87434 EU832086 ACE86748 JF432841 ADZ16058 L07395 AAA19823 X74008 CAA52169 XM_011538504 XP_011536806 XM_011538505 XP_011536807 NM_001244974 NP_001231903 NM_002710 NP_002701 |
| Function | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue |
| Subcellular Location | Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Chromosome, centromere, kinetochore. Cleavage furrow. Midbody. Mitochondrion. Note=Colocalizes with SPZ1 in the nucleus (By similarity). Colocalizes with URI1 at mitochondrion. Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments. Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles. Shows a dynamic targeting to specific sites throughout the cell cycle. Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis. Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase. Also accumulates at the cleavage furrow and midbody by telophase. {ECO:0000250}. |
| Top Pathways | Amphetamine addiction, cGMP-PKG signaling pathway, Oxytocin signaling pathway, cAMP signaling pathway, Inflammatory mediator regulation of TRP channels |
PP1γ CRISPR/Cas9 KO Plasmid (h) - sc-401476 from Santa Cruz Biotechnology
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PP1γ HDR Plasmid (h) - sc-401476-HDR from Santa Cruz Biotechnology
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PP1γ Double Nickase Plasmid (h) - sc-401476-NIC from Santa Cruz Biotechnology
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PP1γ Double Nickase Plasmid (h2) - sc-401476-NIC-2 from Santa Cruz Biotechnology
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PP1γ CRISPR Activation Plasmid (h) - sc-401476-ACT from Santa Cruz Biotechnology
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PP1γ CRISPR Activation Plasmid (h2) - sc-401476-ACT-2 from Santa Cruz Biotechnology
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PP1γ Lentiviral Activation Particles (h) - sc-401476-LAC from Santa Cruz Biotechnology
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PP1γ Lentiviral Activation Particles (h2) - sc-401476-LAC-2 from Santa Cruz Biotechnology
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PP1γ siRNA (h) - sc-36297 from Santa Cruz Biotechnology
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PP1γ shRNA Plasmid (h) - sc-36297-SH from Santa Cruz Biotechnology
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PP1γ shRNA (h) Lentiviral Particles - sc-36297-V from Santa Cruz Biotechnology
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Protein Phosphatase 1C gamma RNAi - H00005501-R02 from Novus Biologicals
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MISSION® esiRNA - EHU082761 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0517 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0519 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0518 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1539 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1539 from Sigma-Aldrich
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PPP1CC siRNA (Human) - CRH3686 from Cohesion Biosciences
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shRNA set against Human PPP1CC (NM_002710.3) - SHH380972 from Creative biogene
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Human PPP1CC siRNA - orb264188 from Biorbyt
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PPP1CC shRNA Plasmid (Human) - CHH3686 from Cohesion Biosciences
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PPP1CC miRNA 3'UTR clone - MiUTR3H-01913 from Creative biogene
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