LRAT

Gene Symbol LRAT
Entrez Gene 9227
Alt Symbol LCA14
Species Human
Gene Type protein-coding
Description lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
Other Description lecithin retinol acyltransferase
Swissprots Q8N716 O95237 A8K983
Accessions EAX04904 O95237 AF071510 AAD13529 AK056234 AK292598 BAF85287 AY546085 AAS49412 AY546086 AAS49413 BC031053 AAH31053 DB364008 DQ266889 GQ129396 ACT64530 GQ129397 ACT64531 JF432615 ADZ15832 XM_006714412 XP_006714475 XR_938793 NM_001301645 NP_001288574 NM_004744 NP_004735
Function Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments. {ECO:0000269|PubMed:9920938}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Rough endoplasmic reticulum {ECO:0000250}. Endosome, multivesicular body {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Present in the rough endoplasmic reticulum and multivesicular body in hepatic stellate cells. Present in the rough endoplasmic reticulum and perinuclear region in endothelial cells (By similarity). {ECO:0000250}.
Tissue Specificity Hepatic stellate cells and endothelial cells (at protein level). Found at high levels in testis and liver, followed by retinal pigment epithelium, small intestine, prostate, pancreas and colon. Low expression observed in brain. In fetal tissues, expressed in retinal pigment epithelium and liver, and barely in the brain. {ECO:0000269|PubMed:18544127, ECO:0000269|PubMed:9920938}.
Top Pathways Vitamin digestion and absorption, Retinol metabolism

LRAT (M34-P1F10) - sc-101391 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LRAT (M34-P1F10): sc-101391. Western blot analysis of LRAT expression in HeLa whole cell lysate.

LRAT (N-15) - sc-49223 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LRAT (N-15): sc-49223. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic staining of glandular cells and interstitial cells.

LRAT (M-48) - sc-99015 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
LRAT (M-48): sc-99015. Western blot analysis of LRAT expression in mouse testis tissue extract.

LRAT (H-83) - sc-99016 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
LRAT (H-83): sc-99016. Immunoperoxidase staining of formalin fixed, paraffin-embedded human duodenum tissue showing cytoplasmic staining of glandular cells.

Anti-LRAT antibody - ab166784 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-LRAT antibody (ab166784) at 1/500 dilutionLane 1 : COLO205 cell extractLane 2 : COLO205 cell extract with immunizing peptide

Anti-LRAT antibody - ab137304 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-LRAT antibody (ab137304) at 1/500 dilution + COLO205 cell lysate at 30 µg

Anti-LRAT Antibody - LS-C194006 from LifeSpan Bioscience

Prices $905.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-LRAT Antibody (aa89-138) - LS-C292145 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-LRAT Antibody - LS-C295105 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LRAT Antibody (Biotin) - LS-C300359 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LRAT Antibody (FITC) - LS-C302173 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LRAT Antibody - LS-C308800 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-LRAT Antibody (aa148-193) - LS-C313815 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LRAT Antibody (aa1-230) - LS-C311594 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-LRAT Antibody (clone 4E12) - LS-C139217 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4E12
Detection limit for recombinant GST tagged LRAT is 0.3 ng/ml as a capture antibody.

Anti-LRAT Antibody (aa51-100) - LS-C145491 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
LRAT antibody LS-C145491 Western blot of 1 Cell lysate. Antibody concentration 1 ug/ml.

Anti-LRAT Antibody - LS-C334848 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of U2OS cell using LRAT antibody. Blue: DAPI for nuclear staining.

Anti-LRAT Antibody (aa111-160) IHC-plus™ - LS-B8398 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-LRAT antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8398 dilution 5 ug/ml.

LRAT Antibody - NBP1-79775 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: LRAT Antibody [NBP1-79775] - Titration: 1.0 ug/ml Positive Control: THP-1 Whole Cell.

LRAT Antibody - NBP1-86488 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: LRAT Antibody [NBP1-86488] - Staining of human duodenum shows strong cytoplasmic positivity in glandular cells.

LRAT Antibody (1A11) - H00009227-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A11
Sandwich ELISA: LRAT Antibody (1A11) [H00009227-M01] - Detection limit for recombinant GST tagged LRAT is approximately 0.3ng/ml as a capture antibody.

LRAT Antibody (4E12) - H00009227-M05 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4E12
Sandwich ELISA: LRAT Antibody (4E12) [H00009227-M05] - Detection limit for recombinant GST tagged LRAT is 0.3 ng/ml as a capture antibody.

Monoclonal Anti-LRAT antibody produced in mouse - SAB1404688 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4E12
<B>Immunoblotting</B><BR/>Monoclonal Anti-LRAT: <B>Cat. No. SAB1404688</B>: Antibody concentration: 1 μg/mL. Specific band of ~37.1 kDa using immunogen protein lysate.

Anti-LRAT antibody produced in rabbit - SAB4503589 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-LRAT: <B>Cat. No. SAB4503589</B>: Immunohistochemistry analysis of paraffin-embedded human prostate carcinoma tissue using Anti-LRAT antibody. Cells on the left were treated with the Anti-LRAT antibody. Cells on the right (negative control) were treated with both Anti-LRAT antibody and the synthesized immunogen peptide.

Monoclonal Anti-LRAT antibody produced in mouse - WH0009227M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A11
<B>Sandwich ELISA</B><BR/>Monoclonal Anti-LRAT, <B>Cat. No. WH0009227M1</B>: the detection limit for recombinant GST tagged LRAT is approximately 0.3ng/mL.
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