LRAT

Gene Symbol	LRAT
Entrez Gene	9227
Alt Symbol	LCA14
Species	Human
Gene Type	protein-coding
Description	lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
Other Description	lecithin retinol acyltransferase
Swissprots	Q8N716 O95237 A8K983
Accessions	EAX04904 O95237 AF071510 AAD13529 AK056234 AK292598 BAF85287 AY546085 AAS49412 AY546086 AAS49413 BC031053 AAH31053 DB364008 DQ266889 GQ129396 ACT64530 GQ129397 ACT64531 JF432615 ADZ15832 XM_006714412 XP_006714475 XR_938793 NM_001301645 NP_001288574 NM_004744 NP_004735
Function	Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments. {ECO:0000269|PubMed:9920938}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Rough endoplasmic reticulum {ECO:0000250}. Endosome, multivesicular body {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Present in the rough endoplasmic reticulum and multivesicular body in hepatic stellate cells. Present in the rough endoplasmic reticulum and perinuclear region in endothelial cells (By similarity). {ECO:0000250}.
Tissue Specificity	Hepatic stellate cells and endothelial cells (at protein level). Found at high levels in testis and liver, followed by retinal pigment epithelium, small intestine, prostate, pancreas and colon. Low expression observed in brain. In fetal tissues, expressed in retinal pigment epithelium and liver, and barely in the brain. {ECO:0000269|PubMed:18544127, ECO:0000269|PubMed:9920938}.
Top Pathways	Vitamin digestion and absorption, Retinol metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LRAT full length protein - ab132834 from Abcam Category Protein Source Wheat germ Species Human

Human LRAT protein fragment - ab160392 from Abcam Category Protein Source Wheat germ Species Human

LRAT Antibody Blocking Peptide - LS-E21883 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human LRAT Protein - H00009227-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human LRAT Protein - H00009227-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

LRAT Blocking Peptide - 33R-4934 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

LRAT Blocking Peptide - abx063566 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey, Rabbit

LRAT - H00009227-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

LRAT - H00009227-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

LRAT - H00009227-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

LRAT - H00009227-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

LRAT fusion protein - ag3556 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

LRAT Blocking Peptide - CBP2372 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey, Rabbit

LRAT Peptide - BS5783P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Lecithin retinol acyltransferase(LRAT) - CSB-YP013069HU CSB-EP013069HU CSB-BP013069HU CSB-MP013069HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

LRAT Recombinant Protein Antigen - NBP1-86488PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

LRAT Peptide, Human - M34GP08831H from Creative Peptides Category Peptide Source Synthetic. Species Human

Lecithin retinol acyltransferase, Recombinant Protein - MBS7043038 from MyBioSource Category Protein Prices $1,045.00, $2,030.00, $3,240.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

Lecithin retinol acyltransferase (LRAT), Recombinant Protein - MBS1228013 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Search more