EIF4EBP2

Gene Symbol EIF4EBP2
Entrez Gene 1979
Alt Symbol 4EBP2, PHASII
Species Human
Gene Type protein-coding
Description eukaryotic translation initiation factor 4E binding protein 2
Other Description 4E-BP2|eIF4E-binding protein 2|eukaryotic translation initiation factor 4E-binding protein 2|phosphorylated, heat and acid stable regulated by insulin protein II
Swissprots Q13542
Accessions CAT01881 EAW54400 EAW54401 EAW54402 Q13542 AK001936 AK057643 AK313724 BAG36466 BC005057 AAH05057 BC015007 BC050633 AAH50633 BG717474 BT007317 AAP35981 CR542240 CAG47036 CR627373 DQ583065 DQ893105 ABM84031 DQ896377 ABM87376 L36056 AAA62270 NM_004096 NP_004087
Function Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity). {ECO:0000250|UniProtKB:P70445, ECO:0000269|PubMed:25533957}.
Top Pathways RNA transport

4E-BP2 Antibody - 2845 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from A673 cells, untreated or nocodazole-treated (100 ng/ml, 16 hrs), using 4E-BP2 Antibody (upper) or 4E-BP1 Antibody #9452 (lower). Extracts were treated with lambda phosphatase NEB#P0753 (10,000 U/ml for 1 hour) to dephosphorylate both proteins.

4E-BP2 (N-14) - sc-74397 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

4E-BP2 (S-16) - sc-74398 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-eIF4EBP2 antibody - ab69529 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-eIF4EBP2 antibody - ab14295 from Abcam

Prices $406.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal
Anti-eIF4EBP2 antibody (ab14295) at 1/2000 dilution + E.coli derived elF4BP2 fusion protein.SecondaryHRP cojugated anti IgY at 1/1000 dilution

Anti-eIF4EBP2 antibody - ab111309 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry Image of Human Pancreas Formalin Fixed and Paraffin Embedded (FFPE) and stained with ab111309 at 10µg/ml. After incubation with the primary antibody, slides were incubated with biotinylated Goat anti Rabbit secondary antibody, followed by alkaline phosphatase streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity.

Anti-4E-BP2 / EIF4EBP2 Antibody (aa87-115) IHC-plus™ - LS-B10370 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-4E-BP2 / EIF4EBP2 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-4E-BP2 / EIF4EBP2 Antibody (clone 2G8) - LS-C197120 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2G8

Anti-4E-BP2 / EIF4EBP2 Antibody (aa87-115, AP) - LS-C208867 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-4E-BP2 / EIF4EBP2 Antibody (aa87-115, APC) - LS-C208868 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-4E-BP2 / EIF4EBP2 Antibody (aa7-56) - LS-C146342 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
EIF4EBP2 / 4EBP2 antibody LS-C146342 Western blot of Mouse Heart lysate. Antibody concentration 1 ug/ml.

Anti-4E-BP2 / EIF4EBP2 Antibody (aa87-115, Biotin) - LS-C208869 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-4E-BP2 / EIF4EBP2 Antibody (aa87-115, FITC) - LS-C208870 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-4E-BP2 / EIF4EBP2 Antibody (aa87-115, Azide-free, HRP) - LS-C208871 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-4E-BP2 / EIF4EBP2 Antibody (aa87-115, PE) - LS-C208872 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-4E-BP2 / EIF4EBP2 Antibody (HRP) - LS-C317009 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-4E-BP2 / EIF4EBP2 Antibody (Biotin) - LS-C317008 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-4E-BP2 / EIF4EBP2 Antibody (FITC) - LS-C317010 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-4E-BP2 / EIF4EBP2 Antibody (FITC) - LS-C317297 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-4E-BP2 / EIF4EBP2 Antibody (HRP) - LS-C317296 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-4E-BP2 / EIF4EBP2 Antibody (aa87-115) - LS-C321074 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-4E-BP2 / EIF4EBP2 Antibody (Biotin) - LS-C317299 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-4E-BP2 / EIF4EBP2 Antibody (aa99-120) IHC-plus™ - LS-B3749 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-EIF4EBP2 / 4EBP2 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3749 concentration 10 ug/ml.

Anti-4E-BP2 / EIF4EBP2 Antibody IHC-plus™ - LS-B12289 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-4E-BP2 / EIF4EBP2 Antibody IHC-plus™ - LS-B12288 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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