EIF4EBP2
| Gene Symbol | EIF4EBP2 |
|---|---|
| Entrez Gene | 1979 |
| Alt Symbol | 4EBP2, PHASII |
| Species | Human |
| Gene Type | protein-coding |
| Description | eukaryotic translation initiation factor 4E binding protein 2 |
| Other Description | 4E-BP2|eIF4E-binding protein 2|eukaryotic translation initiation factor 4E-binding protein 2|phosphorylated, heat and acid stable regulated by insulin protein II |
| Swissprots | Q13542 |
| Accessions | CAT01881 EAW54400 EAW54401 EAW54402 Q13542 AK001936 AK057643 AK313724 BAG36466 BC005057 AAH05057 BC015007 BC050633 AAH50633 BG717474 BT007317 AAP35981 CR542240 CAG47036 CR627373 DQ583065 DQ893105 ABM84031 DQ896377 ABM87376 L36056 AAA62270 NM_004096 NP_004087 |
| Function | Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity). {ECO:0000250|UniProtKB:P70445, ECO:0000269|PubMed:25533957}. |
| Top Pathways | RNA transport |
4E-BP2 CRISPR/Cas9 KO Plasmid (h) - sc-410771 from Santa Cruz Biotechnology
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4E-BP2 HDR Plasmid (h) - sc-410771-HDR from Santa Cruz Biotechnology
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4E-BP2 Double Nickase Plasmid (h) - sc-410771-NIC from Santa Cruz Biotechnology
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4E-BP2 Double Nickase Plasmid (h2) - sc-410771-NIC-2 from Santa Cruz Biotechnology
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4E-BP2 CRISPR Activation Plasmid (h) - sc-410771-ACT from Santa Cruz Biotechnology
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4E-BP2 CRISPR Activation Plasmid (h2) - sc-410771-ACT-2 from Santa Cruz Biotechnology
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4E-BP2 Lentiviral Activation Particles (h) - sc-410771-LAC from Santa Cruz Biotechnology
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4E-BP2 Lentiviral Activation Particles (h2) - sc-410771-LAC-2 from Santa Cruz Biotechnology
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4E-BP2 siRNA (h) - sc-77246 from Santa Cruz Biotechnology
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4E-BP2 shRNA Plasmid (h) - sc-77246-SH from Santa Cruz Biotechnology
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4E-BP2 shRNA (h) Lentiviral Particles - sc-77246-V from Santa Cruz Biotechnology
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eIF4EBP2 RNAi - H00001979-R01 from Novus Biologicals
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MISSION® esiRNA - EHU106291 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7780 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7780 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11064 from Sigma-Aldrich
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EIF4EBP2 siRNA (Human) - CRH1369 from Cohesion Biosciences
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EIF4EBP2 - MBS8205424 from MyBioSource
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shRNA set against Human EIF4EBP2 (NM_004096.4) - SHH284693 from Creative biogene
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shRNA set against Human EIF4EBP2(NM_004096.4) - SHH029919 from Creative biogene
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Human 4E-BP2 siRNA - orb261871 from Biorbyt
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EIF4EBP2 shRNA Plasmid (Human) - CHH1369 from Cohesion Biosciences
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EIF4EBP2 miRNA 3'UTR clone - MiUTR1H-03175 from Creative biogene
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