EIF4EBP2

Gene Symbol EIF4EBP2
Entrez Gene 1979
Alt Symbol 4EBP2, PHASII
Species Human
Gene Type protein-coding
Description eukaryotic translation initiation factor 4E binding protein 2
Other Description 4E-BP2|eIF4E-binding protein 2|eukaryotic translation initiation factor 4E-binding protein 2|phosphorylated, heat and acid stable regulated by insulin protein II
Swissprots Q13542
Accessions CAT01881 EAW54400 EAW54401 EAW54402 Q13542 AK001936 AK057643 AK313724 BAG36466 BC005057 AAH05057 BC015007 BC050633 AAH50633 BG717474 BT007317 AAP35981 CR542240 CAG47036 CR627373 DQ583065 DQ893105 ABM84031 DQ896377 ABM87376 L36056 AAA62270 NM_004096 NP_004087
Function Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity). {ECO:0000250|UniProtKB:P70445, ECO:0000269|PubMed:25533957}.
Top Pathways RNA transport

EIF4EBP2-Over-expression-Lysate - LY12472a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag EIF4EBP2 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the EIF4EBP2 gene

EIF4EBP2 293 Cell Lysate - 408502 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

eIF4EBP2 Overexpression Lysate (Native) - NBL1-10207 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: eIF4EBP2 Overexpression Lysate (Adult Normal) [NBL1-10207] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for eIF4EBP2.

EIF4EBP2 Over-expression Lysate Product - GWB-D306DB from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

eIF4EBP2 Overexpression Lysate (Denatured) - H00001979-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Panoply™ Human EIF4EBP2 Knockdown Stable Cell Line - CSC-DC004833 from Creative biogene

Category Cell Line
Species Human
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