| Gene Symbol |
Notch4
|
| Entrez Gene |
18132
|
| Alt Symbol |
Int-3, Int3, N4
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
notch 4
|
| Other Description |
Notch gene homolog 4|neurogenic locus notch homolog protein 4
|
| Swissprots |
Q62389 Q9R1X0 Q9R1W9 O88316 Q62390 O35442 P31695 O88314
|
| Accessions |
AAB82004 CAM18615 EDL26808 EDL26809 EDL26810 EDL26811 EDL26812 P31695 AK143484 AK166261 AK166493 BC138044 AAI38045 BC145114 M80456 AAB38377 XM_006523798 XP_006523861 XM_006525349 XP_006525412 XR_385298 XR_385939 NM_010929 NP_035059
|
| Function |
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May regulate branching morphogenesis in the developing vascular system. {ECO:0000250, ECO:0000269|PubMed:11344305}.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Highly expressed in lung, moderately in heart kidney, and at lower levels in the ovary and skeletal muscle. A very low expression is seen in the brain, intestine, liver and testis.
|
| Top Pathways |
Notch signaling pathway, MicroRNAs in cancer, Dorso-ventral axis formation
|