Traf6

Gene Symbol Traf6
Entrez Gene 22034
Alt Symbol 2310003F17Rik, AI851288, C630032O20Rik
Species Mouse
Gene Type protein-coding
Description TNF receptor-associated factor 6
Other Description E3 ubiquitin-protein ligase TRAF6
Swissprots Q6P9M0 Q8BLV2 P70196
Accessions EDL27656 EDL27657 P70196 AK009110 AK033718 AK040308 AK041172 BAC30850 AK051130 AK083275 AK155434 BAE33263 BC060705 AAH60705 BY131535 D84655 BAA12705 NM_001303273 NP_001290202 NM_009424 NP_033450
Function E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation (By similarity). Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B- lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. {ECO:000
Subcellular Location Cytoplasm {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Nucleus {ECO:0000250}. Lipid droplet {ECO:0000269|PubMed:21435586}. Note=RSAD2/viperin recruits it to the lipid droplet.
Tissue Specificity Highly expressed in brain, lung, liver, skeletal muscle, and kidney; lower expression in heart, spleen, and testis.
Top Pathways Tuberculosis, Herpes simplex infection, Measles, Pertussis, Epstein-Barr virus infection

TRAF6 Polyclonal Antibody - bs-1184R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded human oral squamous cell carcinoma labeled with Anti-TRAF6 Polyclonal Antibody, Unconjugated (bs-1184R) followed by conjugation to the secondary antibody and DAB staining

TRAF6 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-1184R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TRAF6 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-1184R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TRAF6 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-1184R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TRAF6 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-1184R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TRAF6 Polyclonal Antibody, Cy3 Conjugated - bs-1184R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TRAF6 Polyclonal Antibody, Cy5 Conjugated - bs-1184R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TRAF6 Polyclonal Antibody, Cy5.5 Conjugated - bs-1184R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TRAF6 Polyclonal Antibody, Cy7 Conjugated - bs-1184R-Cy7 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TRAF6 Polyclonal Antibody, FITC Conjugated - bs-1184R-FITC from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TRAF6 Polyclonal Antibody, Biotin Conjugated - bs-1184R-Biotin from Bioss

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TRAF6 Polyclonal Antibody, HRP Conjugated - bs-1184R-HRP from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TRAF6 / RNF85 antibody - AM26628AF-N from Acris Antibodies

Prices $310.00
Sizes 100 µg
Host Hamster
Clonality Monoclonal
Clone 1F8
Western blot analysis of TRAF6 expression in L5178Y (1), WR19L (2) and NIH/3T3 (3) using AM26628AF-N.

Rabbit Anti-Human TRAF6 - DS-PB-01995 from RayBiotech

Host Rabbit

Rabbit Anti-Human TRAF6 - DS-PB-02965 from RayBiotech

Host Rabbit

TRAF6 polyclonal antibody - ADI-AAP-426-E from Enzo Life Sciences

Prices $281.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Polyclonal Antibody to TNF Receptor Associated Factor 6 (TRAF6) - PAG751Mu01 from Cloud-clone

Host Rabbit
Clonality Polyclonal

anti-TRAF6 antibody - ARG54683 from Arigo Biolaboratories

ARG54683 anti-TRAF6 antibody ICC image Immunocytochemistry: K562 cells stained with ARG54683 anti-TRAF6 antibody at 0.5 μg/ml.

TNF Receptor Associated Factor 6, Polyclonal Antibody - MBS2027407 from MyBioSource

Prices $135.00, $165.00, $245.00, $325.00, $505.00, $1,215.00
Sizes 10 µg, 20 µg, 50 µg, 100 µg, 200 µg, 1 mg
Host Rabbit
Clonality Polyclonal

TRAF6 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated - bs-1184R-A594 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TRAF6 / RNF85 antibody - TA352399 from Acris Antibodies

Prices $280.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone T2-1SC
Hela (Lane 1) and 3T3 (Lane 2) cell lysates were resolved by electrophoresis, transferred to nitrocellulose and probed with a monoclonal anti-TRAF6 antibody. Proteins were visualized using a goat anti-mouse-IgG secondary conjugated to HRP and chemiluminescence detection.

TRAF6 Polyclonal Antibody, ALEXA FLUOR® 680 Conjugated - bs-1184R-A680 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TRAF6 Polyclonal Antibody, ALEXA FLUOR® 750 Conjugated - bs-1184R-A750 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TRAF6 Polyclonal Antibody Cy3 Conjugated - C01537Cy3 from Signalway Antibody

Prices $409.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TRAF6 Polyclonal Antibody Cy5 Conjugated - C01537Cy5 from Signalway Antibody

Prices $409.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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