| Gene Symbol | Traf6 |
|---|---|
| Entrez Gene | 22034 |
| Alt Symbol | 2310003F17Rik, AI851288, C630032O20Rik |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | TNF receptor-associated factor 6 |
| Other Description | E3 ubiquitin-protein ligase TRAF6 |
| Swissprots | Q6P9M0 Q8BLV2 P70196 |
| Accessions | EDL27656 EDL27657 P70196 AK009110 AK033718 AK040308 AK041172 BAC30850 AK051130 AK083275 AK155434 BAE33263 BC060705 AAH60705 BY131535 D84655 BAA12705 NM_001303273 NP_001290202 NM_009424 NP_033450 |
| Function | E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation (By similarity). Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B- lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. {ECO:000 |
| Subcellular Location | Cytoplasm {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Nucleus {ECO:0000250}. Lipid droplet {ECO:0000269|PubMed:21435586}. Note=RSAD2/viperin recruits it to the lipid droplet. |
| Tissue Specificity | Highly expressed in brain, lung, liver, skeletal muscle, and kidney; lower expression in heart, spleen, and testis. |
| Top Pathways | Tuberculosis, Herpes simplex infection, Measles, Pertussis, Epstein-Barr virus infection |
TRAF6 CRISPR/Cas9 KO Plasmid (m) - sc-423497 from Santa Cruz Biotechnology
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TRAF6 HDR Plasmid (m) - sc-423497-HDR from Santa Cruz Biotechnology
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TRAF6 Double Nickase Plasmid (m) - sc-423497-NIC from Santa Cruz Biotechnology
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TRAF6 Double Nickase Plasmid (m2) - sc-423497-NIC-2 from Santa Cruz Biotechnology
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TRAF6 CRISPR Activation Plasmid (m) - sc-423497-ACT from Santa Cruz Biotechnology
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TRAF6 CRISPR Activation Plasmid (m2) - sc-423497-ACT-2 from Santa Cruz Biotechnology
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TRAF6 Lentiviral Activation Particles (m) - sc-423497-LAC from Santa Cruz Biotechnology
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TRAF6 Lentiviral Activation Particles (m2) - sc-423497-LAC-2 from Santa Cruz Biotechnology
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TRAF6 siRNA (m) - sc-36718 from Santa Cruz Biotechnology
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TRAF6 shRNA Plasmid (m) - sc-36718-SH from Santa Cruz Biotechnology
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TRAF6 shRNA (m) Lentiviral Particles - sc-36718-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU046421 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN43375 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND43375 from Sigma-Aldrich
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TRAF6 siRNA (Mouse) - CRM4236 from Cohesion Biosciences
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TRAF6 - MBS8210869 from MyBioSource
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shRNA set against Mouse TRAF6 (NM_009424.2) - SHH433776 from Creative biogene
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Mouse TRAF6 siRNA - orb283712 from Biorbyt
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TRAF6 shRNA Plasmid (Mouse) - CHM4236 from Cohesion Biosciences
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TRAF6 miRNA 3'UTR clone - MiUTR1M-12081 from Creative biogene
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