| Gene Symbol |
Traf6
|
| Entrez Gene |
22034
|
| Alt Symbol |
2310003F17Rik, AI851288, C630032O20Rik
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
TNF receptor-associated factor 6
|
| Other Description |
E3 ubiquitin-protein ligase TRAF6
|
| Swissprots |
Q6P9M0 Q8BLV2 P70196
|
| Accessions |
EDL27656 EDL27657 P70196 AK009110 AK033718 AK040308 AK041172 BAC30850 AK051130 AK083275 AK155434 BAE33263 BC060705 AAH60705 BY131535 D84655 BAA12705 NM_001303273 NP_001290202 NM_009424 NP_033450
|
| Function |
E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation (By similarity). Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B- lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. {ECO:000
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Nucleus {ECO:0000250}. Lipid droplet {ECO:0000269|PubMed:21435586}. Note=RSAD2/viperin recruits it to the lipid droplet.
|
| Tissue Specificity |
Highly expressed in brain, lung, liver, skeletal muscle, and kidney; lower expression in heart, spleen, and testis.
|
| Top Pathways |
Tuberculosis, Herpes simplex infection, Measles, Pertussis, Epstein-Barr virus infection
|