MBD4

Gene Symbol MBD4
Entrez Gene 8930
Alt Symbol MED1
Species Human
Gene Type protein-coding
Description methyl-CpG binding domain protein 4
Other Description 3,N(4)-ethenocytosine glycosylase|G/5-fluorouracil mismatch glycosylase with biphasic kinetics|G/T mismatch glycosylase|G/U mismatch glycosylase|methyl-CpG-binding domain protein 4|methyl-CpG-binding endonuclease 1|methyl-CpG-binding protein MBD4|mismatch-specific DNA N-glycosylase|putative methyl-CpG binding protein
Swissprots Q96F09 Q2MD36 D3DNC3 O95243 D3DNC4 B4DZN2 E9PEE4 Q7Z4T3
Accessions AAD50374 AAM00008 EAW79251 EAW79252 EAW79253 EAW79254 EAW79255 O95243 AF072250 AAC68879 AF114784 AAD22195 AF532602 AAP97338 AK303013 BAG64144 AK312878 AM180876 CAJ55826 BC011752 AAH11752 BC034463 BP370521 BY997577 CD678412 CR450305 CAG29301 DB568237 JF432222 ADZ15439 XM_011513267 XP_011511569 XM_011513268 XP_011511570 NM_001276270 NP_001263199 NM_001276271 NP_001263200 NM_001276272 NP_001263201 NM_001276273 NP_001263202 NM_003925 NP_003916
Function Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. {ECO:0000269|PubMed:10097147, ECO:0000269|PubMed:10930409}.
Subcellular Location Nucleus.
Top Pathways Base excision repair

MBD4 (A-8) - sc-365974 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MBD4 (A-8): sc-365974. Western blot analysis of MBD4 expression in SK-MEL-28 nuclear extract.

MBD4 (D-6) - sc-271530 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MBD4 (D-6): sc-271530. Western blot analysis of MBD4 expression in NIH/3T3 whole cell lysate.

MBD4 (G-7) - sc-398249 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MBD4 (G-7): sc-398249. Western blot analysis of MBD4 expression in non-transfected: sc-117752 (A) and mouse MBD4 transfected: sc-121541 (B) 293T whole cell lysates and human skin tissue extract (C).

MBD4 (E-19) - sc-9405 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MBD4 (E-19): sc-9405. Western blot analysis of MBD4 expression in non-transfected: sc-117752 (A) and mouse MBD4 transfected: sc-121541 (B) 293T whole cell lysates.

MBD4 (H-300) - sc-10753 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MBD4 (H-300): sc-10753. Western blot analysis of MBD4 expression in HeLa nuclear extract.

MBD4 (V-18) - sc-9404 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MBD4 (V-18): sc-9404. Western blot analysis of MBD4 expression in non-transfected: sc-117752 (A) and mouse MBD4 transfected: sc-121541 (B) 293T whole cell lysates.

Anti-MBD4 antibody - ab12187 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MBD4 antibody - ab84754 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab84754 at 1/250 dilution staining MBD4 in Human testicular seminoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.

Anti-MBD4 antibody - ab13793 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MBD4 antibody - ab124460 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MBD4 antibody (ab124460) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : MCF7 cell lysateLane 3 : Human fetal liver lysateLane 4 : Human fetal heart lysate

Anti-MBD4 antibody - ab174211 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-MBD4 antibody (ab174211) at 1/100 dilution + SK-BR-3 cell line lysate at 35 µg

Anti-MBD4 antibody - C-terminal - ab191037 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MBD4 antibody - C-terminal (ab191037) at 0.5 µg/mlLane 1 : Rat brain tissue lysateLane 2 : MCF-7 cell lysateLane 3 : HeLa cell lysate

MBD4 Antibody - NBP2-24393 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: MBD4 Antibody [NBP2-24393] - analysis of MBD4 in Jurkat cell lysate (30ug) using anti-MBD4 antibody followed by goat anti-rabbit HRP conjugated secondary antibody (Cat. #NB7160). Image from verified customer review.

MBD4 Antibody - NBP1-91189 from Novus Biologicals

Prices $99.00, $279.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal

MBD4 Antibody - AF5935 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of HepG2 human hepatocellular carcinoma cell line, Raji human Burkitt's lymphoma cell line, and C2C12 mouse myoblast cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse MBD4 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5935) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for MBD4 at approximately 68 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

MBD4 Antibody [DyLight 550] - NBP1-91189R from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MBD4 Antibody [HRP] - NBP1-91189H from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MBD4 Antibody [DyLight 488] - NBP1-91189G from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MBD4 Antibody [DyLight 650] - NBP1-91189C from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MBD4 Antibody [Biotin] - NBP1-91189B from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MBD4 Antibody [Alexa Fluor (R) 700] - NBP1-91189AF700 from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

MBD4 Antibody [Alexa Fluor (R) 647] - NBP1-91189AF647 from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

MBD4 Antibody [Alexa Fluor (R) 488] - NBP1-91189AF488 from Novus Biologicals

Prices $329.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

MBD4 Antibody [Alexa Fluor (R) 405] - NBP1-91189AF405 from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

MBD4 Antibody [FITC] - NBP1-91189F from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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