MBD4

Gene Symbol MBD4
Entrez Gene 8930
Alt Symbol MED1
Species Human
Gene Type protein-coding
Description methyl-CpG binding domain protein 4
Other Description 3,N(4)-ethenocytosine glycosylase|G/5-fluorouracil mismatch glycosylase with biphasic kinetics|G/T mismatch glycosylase|G/U mismatch glycosylase|methyl-CpG-binding domain protein 4|methyl-CpG-binding endonuclease 1|methyl-CpG-binding protein MBD4|mismatch-specific DNA N-glycosylase|putative methyl-CpG binding protein
Swissprots Q96F09 Q2MD36 D3DNC3 O95243 D3DNC4 B4DZN2 E9PEE4 Q7Z4T3
Accessions AAD50374 AAM00008 EAW79251 EAW79252 EAW79253 EAW79254 EAW79255 O95243 AF072250 AAC68879 AF114784 AAD22195 AF532602 AAP97338 AK303013 BAG64144 AK312878 AM180876 CAJ55826 BC011752 AAH11752 BC034463 BP370521 BY997577 CD678412 CR450305 CAG29301 DB568237 JF432222 ADZ15439 XM_011513267 XP_011511569 XM_011513268 XP_011511570 NM_001276270 NP_001263199 NM_001276271 NP_001263200 NM_001276272 NP_001263201 NM_001276273 NP_001263202 NM_003925 NP_003916
Function Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. {ECO:0000269|PubMed:10097147, ECO:0000269|PubMed:10930409}.
Subcellular Location Nucleus.
Top Pathways Base excision repair

MBD4-Over-expression-Lysate - LY11613a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag MBD4 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MBD4 gene

MBD4 overexpression lysate - LY418338 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

MBD4-knockout Cell lysate - LC810281 from Acris Antibodies

Category Cell Lysate
Prices $495.00
Sizes 100 µg

Panoply™ Human MBD4 Knockdown Stable Cell Line - CSC-DC009276 from Creative biogene

Category Cell Line
Species Human

Human MBD4 Knockout Cell Line-HeLa - CSC-RT0747 from Creative biogene

Category Cell Line
Species Human

MBD4 KO Cell Lysate-HeLa - CLKO-0251 from Creative biogene

Category Cell Lysate
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