CCND1

Gene Symbol CCND1
Entrez Gene 595
Alt Symbol BCL1, D11S287E, PRAD1, U21B31
Species Human
Gene Type protein-coding
Description cyclin D1
Other Description B-cell CLL/lymphoma 1|B-cell lymphoma 1 protein|BCL-1 oncogene|G1/S-specific cyclin-D1|PRAD1 oncogene
Swissprots Q6LEF0 P24385
Accessions AAA36481 AAM34300 CAA82318 CDI30198 EAW74746 EAW74747 EAW74748 P24385 AB075505 AK299044 BAG61118 AK313136 BAG35955 AM393193 CAL38071 AM393430 CAL38308 AM393593 CAL38470 AY830112 AAV91344 BC000076 AAH00076 BC001501 AAH01501 BC014078 AAH14078 BC023620 AAH23620 BC025302 AAH25302 BM796500 BT019844 AAV38647 BT019845 AAV38648 CR536538 CAG38775 CR542099 CAG46896 DQ891848 ABM82774 DQ895038 ABM85964 M64349 AAA52136 M73554 AAA58392 M74092 S71637 X59798 CAA42470 XM_006718653 XP_006718716 NM_053056 NP_444284
Function Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. {ECO:0000269|PubMed:15241418, ECO:0000269|PubMe
Subcellular Location Nucleus {ECO:0000269|PubMed:9106657}. Cytoplasm {ECO:0000269|PubMed:9106657}. Membrane {ECO:0000269|PubMed:9106657}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.
Top Pathways MicroRNAs in cancer, Wnt signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Oxytocin signaling pathway

Phospho-Cyclin D1 (Thr286) (D29B3) XP ® Rabbit mAb (PE Conjugate) - 8497 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D29B3
Flow cytometric analysis of HT-1080 cells, MG132 and λ phosphatase-treated (red), untreated (blue), or MG132-treated only (green), using Phospho-Cyclin D1 (Thr286) (D29B3) XP® Rabbit mAb (PE Conjugate).

Phospho-Cyclin D1 (Thr286) (D29B3) XP ® Rabbit mAb - 3300 from Cell Signaling Technology

Prices $119.00, $318.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D29B3
Western blot analysis of extracts from HT-1080 cells, treated with MG132 and with or without λ phosphatase, using Phospho-Cyclin D1 (Thr286) (D29B3) XP ® Rabbit mAb (upper) or Cyclin D1 (DC56) Mouse mAb #2926 (lower).

Cyclin D1 Antibody - 2922 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from C6 and L929 cells, using Cyclin D1 Antibody.

Cyclin D1 (92G2) Rabbit mAb - 2978 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 92G2
Western blot analysis of extracts from MCF7, L929 and C6 cells, using Cyclin D1 (92G2) Rabbit mAb.

Cyclin D1 (DCS6) Mouse mAb - 2926 from Cell Signaling Technology

Host Mouse
Clonality Monoclonal
Clone DCS6
Western blot analysis of extracts from HeLa and NIH/3T3 cells, using Cyclin D1 (DCS) Mouse mAb.

Phospho-Cyclin D1 (Thr286) Antibody - 2921 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from SK-N-MC and C6 cells, untreated or EGF-treated, using Phospho-Cyclin D1 (Thr286) Antibody (upper) or Cyclin D1 mouse mAb #2926 (lower).

cyclin D1 (H-295) - sc-753 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of cyclin D1 expression in C32 nuclear extracts (A-D). Antibodies tested include cyclin D1 (H-295): sc-753 (A,B) and cyclin D1 (M-20): sc-718 (C,D).

cyclin D1 (DCS-6) - sc-20044 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cyclin D1 (DCS-6): sc-20044. Western blot analysis of cyclin D1 expression in C32 (A) and KNRK (B) nuclear extracts.

cyclin D1 (M-20) - sc-718 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
cyclin D1 (M-20): sc-718. Immunofluorescence staining of methanol-fixed C32 cells showing nuclear localization.

cyclin D1 (A-12) - sc-8396 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cyclin D1 (A-12) Alexa Fluor 647 : sc-8396 AF647. Intracellular FCM analysis of fixed and permeabilized KNRK cells. Black line histogram represents the isotype control, normal mouse IgG<sub>2b</sub>: sc-24638.

cyclin D1 (72-13G) - sc-450 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cyclin D1 (72-13G): sc-450. Immunofluorescence staining of methanol-fixed KNRK cells showing mostly nuclear localization.

cyclin D1 (C-20) - sc-717 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
cyclin D1 (C-20): sc-717. Western blot analysis of cyclin D1 expression in C32 (A) and KNRK (B) nuclear extracts.

cyclin D1 (CD1.1) - sc-56302 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
cyclin D1 (CD1.1): sc-56302. Western blot analysis of cyclin D1 expression in C32 (A), KNRK (B) and MCF7 (C) nuclear extracts and C6 whole cell lysate (D).

cyclin D1 (6D328) - sc-70899 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
cyclin D1 (6D328): sc-70899. Western blot analysis of cyclin D1 expression in C32 (A), KNRK (B) and MCF7 (C) nuclear extracts and C6 whole cell lysate (D).

cyclin D1 (HD11) - sc-246 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cyclin D1 (HD11): sc-246. Western blot analysis of cyclin D1 expression in Jurkat whole cell lysate.

cyclin D2 (A-1) - sc-166288 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cyclin D2 (A-1): sc-166288. Western blot analysis of cyclin D2 expression in non-transfected: sc-117752 (A) and human cyclin D2 transfected: sc-111616 (B) 293T whole cell lysates.

cyclin D2 (B-6) - sc-376676 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cyclin D2 (B-6): sc-376676. Western blot analysis of cyclin D2 expression in non-transfected: sc-117752 (A) and human cyclin D2 transfected: sc-111616 (B) 293T whole cell lysates.

Anti-Cyclin D1 (phospho S90) antibody - ab193221 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cyclin D1 (phospho S90) antibody (ab193221) at 1/500 dilutionLane 1 : K562 tissue extractLane 2 : K562 tissue extract with antigen-specific peptide

Anti-Cyclin D1 (phospho S90) antibody - ab196012 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cyclin D1 (phospho S90) antibody (ab196012) at 1/500 dilutionLane 1 : K562 whole cell lysates with antigen-specific peptideLane 2 : K562 whole cell lysatesLysates/proteins at 12.5 µg per lane.

Anti-Cyclin D1 (phospho T286) antibody - ab62151 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cyclin D1 (phospho T286) antibody (ab62151) at 1/500 dilutionLane 1 : Extracts from Jurkat cells treated with EGF (200ng/ml, 30mins)Lane 2 : Extracts from Jurkat cells treated with EGF (200ng/ml, 30mins) with immunizing phosphopeptide

Anti-Cyclin D1 antibody - ab7958 from Abcam

Prices $378.00
Sizes 1 ml
Host Rabbit
Clonality Polyclonal

Anti-Cyclin D1 antibody - ab61758 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Human brain tissue stained with ab61758 at 1/50 dilution, with and without the immunising peptide.

Anti-Cyclin D1 antibody - ab74646 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab74646 stained MCF7 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab74646, 1/1000 dilution) overnight at +4°C. The secondary antibody (green) was ab96899, a goat anti-rabbit DyLight® 488 (IgG; H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Cyclin D1 antibody - ab137819 from Abcam

Prices $372.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Cyclin D1 antibody - ab194972 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-Cyclin D1 antibody (ab194972) at 0.5 µg/ml + human placenta lysate at 35 µgdeveloped using the ECL technique
Search more