CCND1

Gene Symbol	CCND1
Entrez Gene	595
Alt Symbol	BCL1, D11S287E, PRAD1, U21B31
Species	Human
Gene Type	protein-coding
Description	cyclin D1
Other Description	B-cell CLL/lymphoma 1|B-cell lymphoma 1 protein|BCL-1 oncogene|G1/S-specific cyclin-D1|PRAD1 oncogene
Swissprots	Q6LEF0 P24385
Accessions	AAA36481 AAM34300 CAA82318 CDI30198 EAW74746 EAW74747 EAW74748 P24385 AB075505 AK299044 BAG61118 AK313136 BAG35955 AM393193 CAL38071 AM393430 CAL38308 AM393593 CAL38470 AY830112 AAV91344 BC000076 AAH00076 BC001501 AAH01501 BC014078 AAH14078 BC023620 AAH23620 BC025302 AAH25302 BM796500 BT019844 AAV38647 BT019845 AAV38648 CR536538 CAG38775 CR542099 CAG46896 DQ891848 ABM82774 DQ895038 ABM85964 M64349 AAA52136 M73554 AAA58392 M74092 S71637 X59798 CAA42470 XM_006718653 XP_006718716 NM_053056 NP_444284
Function	Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. {ECO:0000269|PubMed:15241418, ECO:0000269|PubMe
Subcellular Location	Nucleus {ECO:0000269|PubMed:9106657}. Cytoplasm {ECO:0000269|PubMed:9106657}. Membrane {ECO:0000269|PubMed:9106657}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.
Top Pathways	MicroRNAs in cancer, Wnt signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Oxytocin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Total Cyclin D1 Sandwich ELISA Kit - 7918 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

SimpleChIP ® Human CCND1 Promoter Primers - 12531 from Cell Signaling Technology Category ChIP Kit Prices $102.00 Sizes 500 µl (250 PCR reactions)

Human CCND1 / Cyclin D1 ELISA Kit (Sandwich ELISA) - LS-F4095 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.313 ng/ml Range 0.313-20 ng/ml

Mouse CCND1 / Cyclin D1 ELISA Kit (Sandwich ELISA) - LS-F4096 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 0.054 ng/ml Range 0.313-20 ng/ml

Mouse/Human/Rat Phospho-CCND1 / Cyclin D1 (Thr286) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1124 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse/Human/Rat CCND1 / Cyclin D1 ELISA Kit (Cell-Based ELISA) - LS-F1925 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse CCND1 / Cyclin D1 ELISA Kit (Sandwich ELISA) - LS-F11067 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.313-20 ng/ml

Rat CCND1 / Cyclin D1 ELISA Kit (Sandwich ELISA) - LS-F11068 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.313-20 ng/ml

Human Cyclin D1 ELISA Kit - abx151222 from Abbexa Category ELISA Kit Sensitivity 0.128 ng/ml Range 0.313 ng/ml - 20 ng/ml

Cyclin-D1, CCND1, Human, ELISA Kit - E-EL-H2092 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Cyclin D1 (CCND1), Human, ELISA Kit - SEA585Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.116ng/mL Range 0.312-20ng/mL

Cyclin D1, Human, ELISA Kit - E01C0483 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 1.0-25ng/ml

G1/S-specific cyclin-D1, CCND1, Human, ELISA Kit - E0585h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

G1/S-specific Cyclin-D1, Human, ELISA Kit - CSB-E08286h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.078 ng/ml Range 0.312 ng/ml-20 ng/ml

Cyclin-D1, CCND1, Mouse, ELISA Kit - E-EL-M0381 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Cyclin D1, CCND1, Rat, ELISA Kit - E-EL-R0294 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Cyclin-D1, CCND1, Rabbit, ELISA Kit - E-EL-RB0820 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Cyclin-D1, CCND1, Chicken, ELISA Kit - E-EL-Ch1170 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Cyclin-D1, CCND1, Porcine, ELISA Kit - E-EL-P0729 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Cyclin-D1, CCND1, Sheep, ELISA Kit - E-EL-S0988 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Cyclin-D1, CCND1, Guinea Pig, ELISA Kit - E-EL-GP0761 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Cyclin-D1, CCND1, Monkey, ELISA Kit - E-EL-MK1094 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

CCND1 (Human) IP-WB Antibody Pair - H00000595-PW2 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human CCND1 ELISA Kit - HC0490 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine CCND1 ELISA Kit - AC0490 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

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