CCND1

Gene Symbol	CCND1
Entrez Gene	595
Alt Symbol	BCL1, D11S287E, PRAD1, U21B31
Species	Human
Gene Type	protein-coding
Description	cyclin D1
Other Description	B-cell CLL/lymphoma 1|B-cell lymphoma 1 protein|BCL-1 oncogene|G1/S-specific cyclin-D1|PRAD1 oncogene
Swissprots	Q6LEF0 P24385
Accessions	AAA36481 AAM34300 CAA82318 CDI30198 EAW74746 EAW74747 EAW74748 P24385 AB075505 AK299044 BAG61118 AK313136 BAG35955 AM393193 CAL38071 AM393430 CAL38308 AM393593 CAL38470 AY830112 AAV91344 BC000076 AAH00076 BC001501 AAH01501 BC014078 AAH14078 BC023620 AAH23620 BC025302 AAH25302 BM796500 BT019844 AAV38647 BT019845 AAV38648 CR536538 CAG38775 CR542099 CAG46896 DQ891848 ABM82774 DQ895038 ABM85964 M64349 AAA52136 M73554 AAA58392 M74092 S71637 X59798 CAA42470 XM_006718653 XP_006718716 NM_053056 NP_444284
Function	Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. {ECO:0000269|PubMed:15241418, ECO:0000269|PubMe
Subcellular Location	Nucleus {ECO:0000269|PubMed:9106657}. Cytoplasm {ECO:0000269|PubMed:9106657}. Membrane {ECO:0000269|PubMed:9106657}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.
Top Pathways	MicroRNAs in cancer, Wnt signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Oxytocin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human CDK6 + CCND1 full length protein - ab84559 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Cyclin D1 peptide - ab8013 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Cyclin D1 peptide - ab188123 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human Cdk4 + Cyclin D1 full length protein - ab55695 from Abcam Category Protein Prices $280.00, $1,810.00 Sizes 10 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

Human Cyclin D1 full length protein - ab85247 from Abcam Category Protein Source E. coli Species Human

CCND1 / Cyclin D1 Antibody Blocking Peptide - LS-E10504 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CCND1 / Cyclin D1 Antibody Blocking Peptide - LS-E10590 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CCND1 / Cyclin D1 Antibody Blocking Peptide - LS-E7807 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CCND1 / Cyclin D1 Antibody Blocking Peptide - LS-E14431 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CCND1 / Cyclin D1 Antibody Blocking Peptide - LS-E11774 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CCND1 / Cyclin D1 Antibody Blocking Peptide - LS-E7012 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Cyclin D1 Recombinant Protein - H00000595-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Cyclin D1 Peptide - P1183 from Novus Biologicals Category Peptide Species Human

CCND1-Antibody-Center-Blocking-Peptide - BP2612c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CCND1-Antibody-N-term-Blocking-Peptide - BP2612a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Cyclin-D1-Antibody-Center-Blocking-peptide - BP14436c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Cyclin-D1-Antibody-S90-Blocking-Peptide - BP2612d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CCND1-Y226-Antibody-Blocking-peptide - BP5314d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Cyclin D1 Protein - GTX108624-pro from GeneTex Category Protein Prices $299.00 Sizes 10 μg Source E. coli Species Human

Cyclin D1 peptide - GTX28013 from GeneTex Category Peptide Prices $179.00 Sizes 100 μg Species Human

Recombinant human G1/S-specific cyclin-D1 (OPCA00039) - OPCA00039 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human CCND1 protein - orb244081 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

CCND1 Blocking Peptide - 33R-1076 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CCND1 Blocking Peptide - 33R-4267 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CCND1 Blocking Peptide - 33R-1077 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

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